Electrical synapses and their functional interactions with chemical synapses

AE Pereda - Nature Reviews Neuroscience, 2014 - nature.com
Brain function relies on the ability of neurons to communicate with each other. Interneuronal
communication primarily takes place at synapses, where information from one neuron is …

Beyond plasticity: the dynamic impact of electrical synapses on neural circuits

P Alcamí, AE Pereda - Nature Reviews Neuroscience, 2019 - nature.com
Electrical synapses are found in vertebrate and invertebrate nervous systems. The cellular
basis of these synapses is the gap junction, a group of intercellular channels that mediate …

[HTML][HTML] Two forms of electrical transmission between neurons

DS Faber, AE Pereda - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Electrical signaling is a cardinal feature of the nervous system and endows it with the
capability of quickly reacting to changes in the environment. Although synaptic communication …

[PDF][PDF] Molecular and functional asymmetry at a vertebrate electrical synapse

…, BD Lynn, FF Bukauskas, JI Nagy, AE Pereda - Neuron, 2013 - cell.com
Electrical synapses are abundant in the vertebrate brain, but their functional and molecular
complexities are still poorly understood. We report here that electrical synapses between …

Trafficking of gap junction channels at a vertebrate electrical synapse in vivo

…, MVL Bennett, JE Rash, AE Pereda - Proceedings of the …, 2012 - National Acad Sciences
Trafficking and turnover of transmitter receptors required to maintain and modify the strength
of chemical synapses have been characterized extensively. In contrast, little is known …

Motoneuron properties during motor inhibition produced by microinjection of carbachol into the pontine reticular formation of the decerebrate cat

…, JK Engelhardt, PJ Soja, AE Pereda… - Journal of …, 1987 - journals.physiology.org
It is well established that cholinergic agonists, when injected into the pontine reticular formation
in cats, produce a generalized suppression of motor activity (1, 3, 6, 14, 18, 27, 33, 50). …

[HTML][HTML] Gap junction-mediated electrical transmission: regulatory mechanisms and plasticity

AE Pereda, S Curti, G Hoge, R Cachope… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The term synapse applies to cellular specializations that articulate the processing of information
within neural circuits by providing a mechanism for the transfer of information between …

Synergy between electrical coupling and membrane properties promotes strong synchronization of neurons of the mesencephalic trigeminal nucleus

S Curti, G Hoge, JI Nagy, AE Pereda - Journal of Neuroscience, 2012 - Soc Neuroscience
Electrical synapses are known to form networks of extensively coupled neurons in various
regions of the mammalian brain. The mesencephalic trigeminal (MesV) nucleus, formed by …

Ca2+/calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission

AE Pereda, TD Bell, BH Chang… - Proceedings of the …, 1998 - National Acad Sciences
While chemical synapses are very plastic and modifiable by defined activity patterns, gap
junctions, which mediate electrical transmission, have been classically perceived as passive …

[HTML][HTML] Electrical synapses in mammalian CNS: Past eras, present focus and future directions

JI Nagy, AE Pereda, JE Rash - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Gap junctions provide the basis for electrical synapses between neurons. Early studies in
well-defined circuits in lower vertebrates laid the foundation for understanding various …