User profiles for Achira Roy

Achira Roy

Assistant Professor, Neuroscience Unit, JNCASR
Verified email at jncasr.ac.in
Cited by 646

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

A Roy, J Skibo, F Kalume, J Ni, S Rankin, Y Lu… - Elife, 2015 - elifesciences.org
10.7554/eLife.12703.001 Mutations in the catalytic subunit of phosphoinositide 3-kinase (PIK3CA)
and other PI3K-AKT pathway components have been associated with cancer and a …

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis

…, N Leviatan, J Hegesh, A Roy… - Proceedings of the …, 2012 - National Acad Sciences
The search for developmental mechanisms driving vertebrate organogenesis has paved the
way toward a deeper understanding of birth defects. During embryogenesis, parts of the …

Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon

G Godbole, AS Shetty, A Roy, L D'Souza… - …, 2018 - journals.biologists.com
During forebrain development, a telencephalic organizer called the cortical hem is crucial for
inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted …

[HTML][HTML] Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

A Roy, KJ Millen, RP Kapur - Acta neuropathologica communications, 2020 - Springer
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss,
gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal …

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis

A Roy, J de Melo, D Chaturvedi, T Thein… - Journal of …, 2013 - Soc Neuroscience
Eye formation is regulated by a complex network of eye field transcription factors (EFTFs),
including LIM-homeodomain gene LHX2. We disrupted LHX2 function at different stages …

Lhx2 regulates the development of the forebrain hem system

A Roy, M Gonzalez-Gomez, A Pierani, G Meyer… - Cerebral …, 2014 - academic.oup.com
Early brain development is regulated by the coordinated actions of multiple signaling centers
at key boundaries between compartments. Three telencephalic midline structures are in a …

[PDF][PDF] Mutations in CRADD result in reduced caspase-2-mediated neuronal apoptosis and cause megalencephaly with a rare lissencephaly variant

…, BD Krewson, AB Shupp, MI Avrutsky, A Roy… - The American Journal of …, 2016 - cell.com
Lissencephaly is a malformation of cortical development typically caused by deficient neuronal
migration resulting in cortical thickening and reduced gyration. Here we describe a "thin" …

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

A Roy, RM Murphy, M Deng, JW MacDonald… - elife, 2019 - elifesciences.org
10.7554/eLife.45961.001 Mechanisms driving the initiation of brain folding are incompletely
understood. We have previously characterized mouse models recapitulating human PIK3CA…

Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream

D Huilgol, S Udin, T Shimogori, B Saha, A Roy… - Nature …, 2013 - nature.com
The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated
in mediating social behavior. It receives input from the vomeronasal organ and projects to …

Suppression of PIK3CA-driven epileptiform activity by acute pathway control

A Roy, VZ Han, AM Bard, DT Wehle, SEP Smith… - bioRxiv, 2021 - biorxiv.org
Patients harboring mutations in the PI3K-AKT-MTOR signaling pathway often develop a
spectrum of neurodevelopmental disorders including epilepsy. A significant proportion of them …