[HTML][HTML] Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression

…, C Tauxe, MA Thomas, C Münster, A Chraïbi… - The EMBO …, 2001 - embopress.org
The epithelial Na+ channel (ENaC) plays an essential role in the regulation of whole body
Na+ balance and blood pressure. The cell surface expression of this channel, a complex of …

An epithelial serine protease activates the amiloride-sensitive sodium channel

V Vallet, A Chraibi, HP Gaeggeler, JD Horisberger… - Nature, 1997 - nature.com
Sodium balance, and ultimately blood pressure and extracellular fluid volume, is maintained
by precise regulation of the activity of the epithelial sodium channel (ENaC) 1 , 2 , 3 . In a …

Protease Modulation of the Activity of the Epithelial Sodium Channel Expressed in Xenopus Oocytes

A Chraïbi, V Vallet, D Firsov, SK Hess… - The Journal of general …, 1998 - rupress.org
We have investigated the effect of extracellular proteases on the amiloride-sensitive Na +
current (I Na ) in Xenopus oocytes expressing the three subunits α, β, and γ of the rat or …

Na self inhibition of human epithelial Na channel: temperature dependence and effect of extracellular proteases

A Chraïbi, JD Horisberger - The Journal of general physiology, 2002 - rupress.org
The regulation of the open probability of the epithelial Na + channel (ENaC) by the
extracellular concentration of Na + , a phenomenon called “Na + self inhibition,” has been well …

[HTML][HTML] Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its α subunit

O Bonny, A Chraibi, J Loffing… - The Journal of …, 1999 - Am Soc Clin Investig
The autosomal recessive form of type I pseudohypoaldosteronism (PHA-I) is an inherited
salt-losing syndrome resulting from diminution-of-function mutations in the 3 subunits of the …

The chemokine CCL2 increases Nav1. 8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism

…, J Van Steenwinckel, N Beaudet, A Chraibi… - Journal of …, 2011 - Soc Neuroscience
Changes in function of voltage-gated sodium channels in nociceptive primary sensory neurons
participate in the development of peripheral hyperexcitability that occurs in neuropathic …

[HTML][HTML] Proven infection-related sepsis induces a differential stress response early after ICU admission

…, N Gallo-Payet, R Dumaine, P Sarret, A Chraibi… - Critical Care, 2010 - Springer
Introduction Neuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived
factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis observed in septic …

[HTML][HTML] Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

…, M Biet, N Beaudet, R Dumaine, A Chraibi… - Journal of …, 2014 - Springer
Background Functional alterations in the properties of Aβ afferent fibers may account for the
increased pain sensitivity observed under peripheral chronic inflammation. Among the …

Modulation of canine cardiac sodium current by Apelin

…, C Antzelevitch, O Lesur, A Chraibi… - Journal of Molecular and …, 2010 - Elsevier
Apelin, a ligand of the G protein-coupled putative angiotensin II-like receptor (APJ-R), exerts
strong vasodilating, cardiac inotropic and chronotropic actions. Its expression is highly up-…

Epithelial sodium channel: a ligand-gated channel?

JD Horisberger, A Chraïbi - Nephron Physiology, 2004 - karger.com
The epithelial sodium channel (ENaC) is a key component of the transepithelial Na+ transport.
In epithelia, it is responsible for the maintenance of Na+ balance (which in turn controls …