[PDF][PDF] TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics

…, C Pottier, K Annu, M Baker, RB Perkerson, A Kurti… - Neuron, 2017 - cell.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

…, CW Lee, K Jansen-West, A Kurti… - Science, 2015 - science.org
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…

Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function

…, ZS Quicksall, C Linares, J Knight, Y Chen, A Kurti… - Nature …, 2022 - nature.com
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer’s disease,
is abundantly expressed in both the brain and periphery. Here, we present evidence that …

[HTML][HTML] Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

SS Kang, PR Jeraldo, A Kurti, MEB Miller… - Molecular …, 2014 - Springer
Background The ingestion of a high-fat diet (HFD) and the resulting obese state can exert a
multitude of stressors on the individual including anxiety and cognitive dysfunction. Though …

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

…, M Yue, J Chew, M Castanedes-Casey, A Kurti… - Nature …, 2016 - nature.com
Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

…, Y Song, SR Pickles, M Castanedes-Casey, A Kurti… - Nature medicine, 2018 - nature.com
The major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis
(ALS) is a C9orf72 G 4 C 2 repeat expansion 1 , 2 . Proposed mechanisms by which the …

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

…, Y Song, JW Andersen, M Castanedes-Casey, A Kurti… - Science, 2019 - science.org
INTRODUCTION Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)
are fatal neurodegenerative diseases that share clinical and neuropathological features. …

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease

…, A Alnobani, J Knight, Y Chen, C Linares, A Kurti… - Nature …, 2023 - nature.com
Microglial involvement in Alzheimer’s disease (AD) pathology has emerged as a risk-determining
pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …

[HTML][HTML] Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

SS Kang, A Kurti, DA Fair, JD Fryer - Journal of neuroinflammation, 2014 - Springer
Obesity induces a low-grade inflammatory state and has been associated with behavioral
and cognitive alterations. Importantly, maternal environmental insults can adversely impact …

ABCA7 deficiency accelerates amyloid-β generation and Alzheimer's neuronal pathology

…, M Tachibana, L Younkin, A Kurti… - Journal of …, 2016 - Soc Neuroscience
In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in
the brain is a central event. Aβ is cleaved from amyloid precursor protein (APP) by β-…