Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines

…, R Conley, D Hallett, AC Humphries… - Journal of …, 2005 - Soc Neuroscience
The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective
benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain controversial. Hence, …

8-Fluoroimidazo [1, 2-a] pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo [1, 2-a] pyrimidine in an allosteric …

AC Humphries, E Gancia, MT Gilligan… - Bioorganic & medicinal …, 2006 - Elsevier
8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of
imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel …

Total synthesis of the protein phosphatase inhibitor okadaic acid

SV Ley, AC Humphries, H Eick, R Downham… - Journal of the …, 1998 - pubs.rsc.org
… Accordingly, the diphenylphosphine oxide 17 was deprotonated with LDA at 78 C and
reacted with the aldehyde 21. Treatment of the initially formed adduct with potassium tertbutoxide …

The Asymmetric Maitland−Japp Reaction and Its Application to the Construction of the C1−C19 Bis-pyran Unit of Phorboxazole B

…, S Santos, N Mistry, L Burroughs, AC Humphries - Organic …, 2011 - ACS Publications
The synthesis of the C1−C19 bis-pyran unit of phorboxazole B has been achieved. The key
pyran rings were constructed by means of an asymmetric Maitland−Japp reaction and a …

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia

LR Fish, MT Gilligan, AC Humphries, M Ivarsson… - Bioorganic & medicinal …, 2005 - Elsevier
Incorporation of fluorine at the 4-position of an existing series of sulfonyl piperidine 5-HT 2A
antagonists gave compounds with increased selectivity over the IKr potassium channel. This …

[HTML][HTML] Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

…, D Smith, L Botham, C Williams, C Alexander… - The Lancet, 2017 - thelancet.com
Background Limits on the frequency of whole blood donation exist primarily to safeguard
donor health. However, there is substantial variation across blood services in the maximum …

A Brønsted acid mediated cascade enone synthesis from aldehydes containing a tethered propargylsilane

…, PJ Jervis, BM Kariuki, AC Humphries… - The Journal of …, 2008 - ACS Publications
MeSO 3 H effects the intramolecular allenylation of a series of aldehydes 1 to provide
allenyl alcohol product 3 as a single diastereoisomer. Cyclization proceeds rapidly at −78 C. …

Using a temporary silicon connection in a highly stereoselective synthesis of a new class of cyclic allenylsilanes

R Ramalho, J Beignet, AC Humphries, LR Cox - Synthesis, 2005 - thieme-connect.com
Aldehyde 4 reacts in the presence of TMSOTf and an acid scavenger to provide the corresponding
oxasilacycle 5 in very good yield and as a single diastereoisomer. The sense of 1, 3-…

Enantioselective Catalysis Using Sterically and Electronically Unsymmetrical Ligands

AC Humphries, A Pfaltz - Stimulating Concepts in Chemistry, 2000 - Wiley Online Library
Sterically and electronically unsymmetrical P,N‐ligands have been designed to incorporate
two types of coordinating units, eg a phosphine group and a nitrogen‐containing heterocycle…

[BOOK][B] A city is not a tree

C Alexander - 2017 - books.google.com
… First and foremost, the authors and publishers are greatly indebted to Christopher Alexander
for writing the original paper included herein, and to him and his wife Maggie Alexander for …