User profiles for Alexander G. Murley

Alexander Murley

University of Cambridge
Verified email at nhs.net
Cited by 684

Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes

AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li… - Brain, 2020 - academic.oup.com
The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous
and overlapping clinical features. There has been great progress in the refinement of clinical …

GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition

AG Murley, MA Rouse, PS Jones, R Ye, FH Hezemans… - Brain, 2020 - academic.oup.com
Behavioural disinhibition is a common feature of the syndromes associated with frontotemporal
lobar degeneration (FTLD). It is associated with high morbidity and lacks proven …

Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes

AG Murley, MA Rouse, ITS Coyle-Gilchrist… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective To test the hypothesis that in syndromes associated with frontotemporal lobar
degeneration, behavioural impairment predicts loss of functional independence and motor …

Co‐occurrence of apathy and impulsivity in progressive supranuclear palsy

ZQ Kok, AG Murley, T Rittman, J Rowe… - Movement Disorders …, 2021 - Wiley Online Library
Background Apathy and impulsivity are common consequences of progressive supranuclear
palsy (PSP) and can worsen its prognosis. They can co‐exist in the same patients although …

Neurotransmitter deficits from frontotemporal lobar degeneration

AG Murley, JB Rowe - Brain, 2018 - academic.oup.com
Frontotemporal lobar degeneration causes a spectrum of complex degenerative disorders
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease

…, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley… - Brain, 2021 - academic.oup.com
Cognitive decline is a common feature of Parkinson’s disease, and many of these cognitive
deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory …

Incidence of syndromes associated with frontotemporal lobar degeneration in 9 European countries

…, A Gabilondo, J Krüger, AG Murley… - JAMA …, 2023 - jamanetwork.com
Importance Diagnostic incidence data for syndromes associated with frontotemporal lobar
degeneration (FTLD) in multinational studies are urgent in light of upcoming therapeutic …

[HTML][HTML] Reduced glutamate turnover in the putamen is linked with automatic habits in human cocaine addiction

KD Ersche, TV Lim, AG Murley, C Rua, MM Vaghi… - Biological …, 2021 - Elsevier
Background The balance between goal-directed behavior and habits has been hypothesized
to be biased toward the latter in individuals with cocaine use disorder (CUD), suggesting …

Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy

…, N Holland, M Malpetti, AG Murley… - Journal of …, 2023 - Soc Neuroscience
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) both impair response
inhibition, exacerbating impulsivity. Inhibitory control deficits vary across individuals and are …

GABAergic cortical network physiology in frontotemporal lobar degeneration

…, MA Rouse, HN Phillips, AD Shaw, AG Murley… - Brain, 2021 - academic.oup.com
The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous,
including the behavioural variant frontotemporal dementia (bvFTD) and progressive …