We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Background The pathological complete response (pCR) after neoadjuvant chemotherapy is
a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of …

Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide …

Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules
with relevance as regulators of gene expression thereby affecting crucial processes in cancer …

Importance Cytotoxic CD8 + tumor-infiltrating lymphocytes (TILs) participate in immune control
of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8 + …

Detection and adaptation to cold temperature is crucial to survival. Cold sensing in the
innocuous range of cold (>10–15 C) in the mammalian peripheral nervous system is thought to …

The breast cancer risk variants identified in genome-wide association studies explain only a
small fraction of the familial relative risk, and the genes responsible for these associations …

Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with
a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-…