We live in a world imbued with a rich mixture of complex sounds. Successful acoustic
communication requires the ability to extract meaning from those sounds, even when degraded. …

The auditory system consists of an intricate set of connections interposed between hierarchically
arranged nuclei. The ascending pathways carrying sound information from the cochlea …

Sensory processing is frequently conceptualized as a linear flow of information from peripheral
receptors through hierarchically organized brain regions, ultimately reaching the cortex. …

The lateral cortex of the inferior colliculus receives information from both auditory and
somatosensory structures and is thought to play a role in multisensory integration. Previous studies …

The extensive feedback from the auditory cortex (AC) to the inferior colliculus (IC) supports
critical aspects of auditory behavior but has not been extensively characterized. Previous …

The lateral cortex of the inferior colliculus (LCIC) forms a nexus between diverse multisensory,
motor, and neuromodulatory streams. Like other integration hubs, it contains repeated …

Sensory systems must account for both contextual factors and prior experience to adaptively
engage with the dynamic external environment. In the central auditory system, neurons …

Key questions about the thalamus are still unanswered in part because of the inability to
stimulate its inputs while monitoring cortical output. To address this, we employed flavoprotein …

Descending projections from the thalamus and related structures to the midbrain are
evolutionarily highly conserved. However, the basic organization of this auditory thalamotectal …

Tight coupling of neuronal metabolism to synaptic activity is critical to ensure that the supply
of metabolic substrates meets the demands of neuronal signaling. Given the impact of …