Chemico-genetic discovery of astrocytic control of inhibition in vivo

T Takano, JT Wallace, KT Baldwin, AM Purkey, A Uezu… - Nature, 2020 - nature.com
Perisynaptic astrocytic processes are an integral part of central nervous system synapses 1 ,
2 ; however, the molecular mechanisms that govern astrocyte–synapse adhesions and how …

[HTML][HTML] Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity

AM Purkey, ML Dell'Acqua - Frontiers in synaptic neuroscience, 2020 - frontiersin.org
Experience-dependent learning and memory require multiple forms of plasticity at hippocampal
and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and …

[PDF][PDF] AKAP150 palmitoylation regulates synaptic incorporation of Ca2+-permeable AMPA receptors to control LTP

AM Purkey, KM Woolfrey, KC Crosby, DG Stich… - Cell reports, 2018 - cell.com
Ca 2+ -permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but
lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term …

[PDF][PDF] Local miRNA-dependent translational control of GABAAR synthesis during inhibitory long-term potentiation

D Rajgor, AM Purkey, JL Sanderson, TM Welle… - Cell reports, 2020 - cell.com
Molecular mechanisms underlying plasticity at brain inhibitory synapses remain poorly
characterized. Increased postsynaptic clustering of GABA A receptors (GABA A Rs) rapidly …

Cnksr2 loss in mice leads to increased neural activity and behavioral phenotypes of epilepsy-aphasia syndrome

E Erata, Y Gao, AM Purkey, EJ Soderblom… - Journal of …, 2021 - Soc Neuroscience
Epilepsy Aphasia Syndromes (EAS) are a spectrum of childhood epileptic, cognitive, and
language disorders of unknown etiology. CNKSR2 is a strong X-linked candidate gene …

Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism

DG Mitchem, AM Purkey, NM Grebe, G Carey… - Behavior Genetics, 2014 - Springer
Human facial attractiveness and facial sexual dimorphism (masculinity–femininity) are
important facets of mate choice and are hypothesized to honestly advertise genetic quality. …

[HTML][HTML] Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines

X Chen, KC Crosby, A Feng, AM Purkey… - Frontiers in Synaptic …, 2022 - frontiersin.org
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling
proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and …

[HTML][HTML] A-kinase anchoring protein 79/150 recruits protein kinase C to phosphorylate roundabout receptors

…, JL Whiting, PJ Nygren, AM Purkey, M Colledge… - Journal of Biological …, 2015 - ASBMB
Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected
substrates to control the efficacy, context, and duration of neuronal phosphorylation events…

Understanding the role of AKAP150 palmitoylation in synaptic plasticity

AM Purkey - 2019 - search.proquest.com
Ca 2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but
lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term …

[PDF][PDF] Purkey et al 2018 Cell Reports. pdf

A Purkey, KM Woolfrey, K Crosby, DG Stich, W Chick… - 2019 - hra.figshare.com
Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but
lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term …