Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

…, CR Barberi, LR Beck, AL Blaker… - G3: Genes …, 2015 - academic.oup.com
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila
melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate …

Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity

AL Blaker, ER Moore… - Journal of …, 2019 - Wiley Online Library
A significant comorbidity exists between alcohol and methamphetamine (Meth) abuse but
the neurochemical consequences of this co‐abuse are unknown. Alcohol and Meth …

Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism

AL Blaker, EA Rodriguez, BK Yamamoto - Brain, behavior, and immunity, 2019 - Elsevier
A significant co-morbidity exists between alcohol and methamphetamine (Meth) in humans
but the consequences and mechanisms underlying their co-morbid effects remain to be …

Methamphetamine-induced brain injury and alcohol drinking

AL Blaker, BK Yamamoto - Journal of neuroimmune pharmacology, 2018 - Springer
A majority of methamphetamine (Meth) abusers also abuse alcohol but the neurochemical
consequences of this co-abuse are unknown. Individually, alcohol and Meth cause …

[HTML][HTML] Escape and avoidance learning in the earthworm Eisenia hortensis

WJ Wilson, NC Ferrara, AL Blaker, CE Giddings - PeerJ, 2014 - peerj.com
Interest in instrumental learning in earthworms dates back to 1912 when Yerkes concluded
that they can learn a spatial discrimination in a T-maze. Rosenkoetter and Boice determined …

Peripheral influences of methamphetamine neurotoxicity

AL Blaker, NA Northrop, BK Yamamoto - Neuropathology of Drug …, 2016 - Elsevier
Methamphetamine (METH) is a psychostimulant that is widely known to act directly upon the
central nervous system (CNS) and to produce damage to the dopaminergic and …

Identifying the role of novel protein kinase C isoforms in mediating paclitaxel-induced peripheral neuropathy

AL Blaker, CM Mitchell, EA Semple - Journal of Neuroscience, 2015 - Soc Neuroscience
Paclitaxel (Taxol) is a commonly prescribed chemotherapeutic drug that stabilizes microtubules
and consequently prevents progression of mitosis in rapidly dividing tumor cells. Like …

Inflammation Produced by Alcohol Synergizes with Methamphetamine to Cause Dopaminergic Deficits

AL Blaker, BK Yamamoto - The FASEB Journal, 2018 - Wiley Online Library
Alcohol and methamphetamine (Meth) are often co‐abused, in that ~77% of Meth addicts
also display an alcohol use disorder. However, the neurochemical consequences of this …

Chronic social defeat stress and cocaine sensitization by sex: the role of glutamate‐glutamine cycle

A Shimamoto, V Rappeneau, AL Blaker… - The FASEB …, 2017 - Wiley Online Library
Background Approximately 8 millions of Americans are suffering from comorbid substance
use disorders (SUD) and mental illnesses, including mood disorders. The risk of drug abuse …

[HTML][HTML] Disruption of the glutamate–glutamine cycle involving astrocytes in an animal model of depression for males and females

V Rappeneau, A Blaker, JR Petro… - Frontiers in behavioral …, 2016 - frontiersin.org
Background: Women are twice as likely as men to develop major depression. The brain
mechanisms underlying this sex disparity are not clear. Disruption of the glutamate–glutamine …