[HTML][HTML] Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
While stressful life events are an important cause of psychopathology, most individuals
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …
Mania-like behavior induced by disruption of CLOCK
K Roybal, D Theobold, A Graham… - Proceedings of the …, 2007 - National Acad Sciences
Circadian rhythms and the genes that make up the molecular clock have long been
implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central …
implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central …
[PDF][PDF] Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
Previous work has identified alterations in histone acetylation in animal models of drug
addiction and depression. However, the mechanisms which integrate drugs and stress with …
addiction and depression. However, the mechanisms which integrate drugs and stress with …
Nuclear factor κB signaling regulates neuronal morphology and cocaine reward
Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc)
neurons have been correlated with behavioral sensitization, the molecular pathways …
neurons have been correlated with behavioral sensitization, the molecular pathways …
Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
…, J Kumar, S Chakravarty, A Asaithamby, A Graham… - Biological …, 2010 - Elsevier
BACKGROUND: Circadian rhythm abnormalities are strongly associated with bipolar
disorder; however the role of circadian genes in mood regulation is unclear. Previously, we …
disorder; however the role of circadian genes in mood regulation is unclear. Previously, we …
Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the …
…, AR Graham, S Unterberg, DL Graham… - Biological …, 2010 - Elsevier
BACKGROUND: Previous research has shown that rats reared in an enriched condition (EC)
are more sensitive to the acute effects of amphetamine than rats reared in an isolated …
are more sensitive to the acute effects of amphetamine than rats reared in an isolated …
Role of nuclear factor κB in ovarian hormone-mediated stress hypersensitivity in female mice
BACKGROUND: The molecular mechanisms of stress-induced depressive behaviors have
been characterized extensively in male rodents; however, much less is known about female …
been characterized extensively in male rodents; however, much less is known about female …
[HTML][HTML] Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 …
…, MM Sidor, SG Birnbaum, A Graham… - …, 2011 - nature.com
Lithium has been used extensively for mood stabilization, and it is particularly efficacious in
the treatment of bipolar mania. Like other drugs used in the treatment of psychiatric diseases, …
the treatment of bipolar mania. Like other drugs used in the treatment of psychiatric diseases, …
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward
BACKGROUND: Previous studies found that brain-derived neurotrophic factor (BDNF) derived
from nucleus accumbens (NAc) neurons can mediate persistent behavioral changes that …
from nucleus accumbens (NAc) neurons can mediate persistent behavioral changes that …
[HTML][HTML] Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior
…, SA Golden, M Heshmati, A Graham… - …, 2012 - nature.com
Inhibitor of κB kinase (IκK) has historically been studied in the context of immune response
and inflammation, but recent evidence demonstrates that IκK activity is necessary and …
and inflammation, but recent evidence demonstrates that IκK activity is necessary and …