Deficiency in Na, K-ATPase α isoform genes alters spatial learning, motor activity, and anxiety in mice
AE Moseley, MT Williams, TL Schaefer… - Journal of …, 2007 - Soc Neuroscience
Several disorders have been associated with mutations in Na,K-ATPase α isoforms (rapid-onset
dystonia parkinsonism, familial hemiplegic migraine type-2), as well as reduction in Na,K…
dystonia parkinsonism, familial hemiplegic migraine type-2), as well as reduction in Na,K…
[HTML][HTML] The Na, K-ATPase α2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice
AE Moseley, SP Lieske, RK Wetzel, PF James… - Journal of Biological …, 2003 - ASBMB
Na,K-ATPase is an ion transporter that impacts neural and glial physiology by direct
electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-type …
electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-type …
The α1- and α2-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility
S He, DA Shelly, AE Moseley… - American Journal …, 2001 - journals.physiology.org
The Na-K-ATPase, which maintains the Na + and K + gradients across the plasma membrane,
can play a major role in modulation of skeletal muscle contractility. Although both α 1 - …
can play a major role in modulation of skeletal muscle contractility. Although both α 1 - …
Na, K-ATPase and the role of α isoforms in behavior
…, MT Williams, CV Vorhees, AE Moseley - Journal of bioenergetics …, 2007 - Springer
The Na,K-ATPase is composed of multiple isoforms and the isoform distribution varies with
the tissue and during development. The α1 isoform for example, is the major isoform in the …
the tissue and during development. The α1 isoform for example, is the major isoform in the …
Physiological role of the α1- and α2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site
…, JC Neumann, AE Moseley… - American Journal …, 2006 - journals.physiology.org
An interesting feature of Na + -K + -ATPase is that it contains four isoforms of the catalytic α-subunit,
each with a tissue-specific distribution. Our laboratory has used gene targeting to …
each with a tissue-specific distribution. Our laboratory has used gene targeting to …
Targeted mutations in the Na, K‐ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice
TL Schaefer, JB Lingrel, AE Moseley, CV Vorhees… - Synapse, 2011 - Wiley Online Library
Sodium and potassium‐activated adenosine triphosphatases (Na,K‐ATPase) are ubiquitous,
participate in osmotic balance and membrane potential, and are composed of α, β, and γ …
participate in osmotic balance and membrane potential, and are composed of α, β, and γ …
The Na+-K+-ATPase α2-subunit isoform modulates contractility in the perinatal mouse diaphragm
TL Radzyukevich, AE Moseley… - … of Physiology-Cell …, 2004 - journals.physiology.org
This study uses genetically altered mice to examine the contribution of the Na + -K + -ATPase
α 2 catalytic subunit to resting potential, excitability, and contractility of the perinatal …
α 2 catalytic subunit to resting potential, excitability, and contractility of the perinatal …
Na, K‐ATPase α2 inhibition alters calcium responses in optic nerve astrocytes
AK Hartford, ML Messer, AE Moseley, JB Lingrel… - Glia, 2004 - Wiley Online Library
Experiments were conducted to test the effect of 1 μM ouabain, an Na,K‐ATPase inhibitor,
on capacitative calcium entry (CCE) and calcium responses elicited by ATP in rat optic nerve …
on capacitative calcium entry (CCE) and calcium responses elicited by ATP in rat optic nerve …
Enhanced pressor response to increased CSF sodium concentration and to central ANG I in heterozygous α2 Na+-K+-ATPase knockout mice
…, I Dostanic-Larson, AE Moseley… - American Journal …, 2009 - journals.physiology.org
Intracerebroventricular (ICV) infusion of NaCl mimics the effects of a high-salt diet in salt-sensitive
hypertension, raising the sodium concentration in the cerebrospinal fluid (CSF [Na]) …
hypertension, raising the sodium concentration in the cerebrospinal fluid (CSF [Na]) …
Attenuation of cardiac contractility in Na, K-ATPase α1 isoform-deficient hearts under reduced calcium conditions
AE Moseley, MH Cougnon, IL Grupp… - Journal of molecular and …, 2004 - Elsevier
We have previously reported that genetic reduction of the Na,K-ATPase α1 isoform (α1 +/– )
results in a hypocontractile cardiac phenotype. This observation was surprising and …
results in a hypocontractile cardiac phenotype. This observation was surprising and …