Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate

CK Naughton, S Jain, AM Strickland… - Biology of …, 2006 - academic.oup.com
Normal spermatogenesis is essential for reproduction and depends on proper spermatogonial
stem cell (SSC) function. Genes and signaling pathways that regulate SSC function have …

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

S Geisler, RA Doan, A Strickland, X Huang, J Milbrandt… - Brain, 2016 - academic.oup.com
Peripheral polyneuropathy is a common and dose-limiting side effect of many important
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …

[PDF][PDF] Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy

A Viader, Y Sasaki, S Kim, A Strickland, CS Workman… - Neuron, 2013 - cell.com
Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has
been devoted to examining the role played by neuronal/axonal mitochondria, but how …

Predictors of patient-assessed illness severity in irritable bowel syndrome

B Spiegel, A Strickland, BD Naliboff… - Official journal of the …, 2008 - journals.lww.com
BACKGROUND Conceptual models suggest that “irritable bowel syndrome (IBS) severity” is
a multidimensional outcome that is related to, yet distinct from, health-related quality of life (…

Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis

S Jain, CK Naughton, M Yang, A Strickland, K Vij… - 2004 - journals.biologists.com
The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived
neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. …

[HTML][HTML] Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

AJ Bloom, X Mao, A Strickland, Y Sasaki… - Molecular …, 2022 - Springer
Background In response to injury, neurons activate a program of organized axon self-destruction
initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, …

[HTML][HTML] Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

S Geisler, SX Huang, A Strickland, RA Doan… - Journal of Experimental …, 2019 - rupress.org
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological
disorders is an active process driven by SARM1, an injury-activated NADase. Axons of …

[HTML][HTML] A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model

Y Sato-Yamada, A Strickland, Y Sasaki… - The Journal of …, 2022 - Am Soc Clin Investig
Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …

Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons

…, RA Barve, SE Maloney, A Strickland… - Journal of …, 2018 - Soc Neuroscience
CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates
gene expression by modifying 3D chromatin structure. Human mutations in CTCF cause …

Schwann cell O-GlcNAc glycosylation is required for myelin maintenance and axon integrity

S Kim, JC Maynard, Y Sasaki, A Strickland… - Journal of …, 2016 - Soc Neuroscience
Schwann cells (SCs), ensheathing glia of the peripheral nervous system, support axonal
survival and function. Abnormalities in SC metabolism affect their ability to provide this support …