Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate
CK Naughton, S Jain, AM Strickland… - Biology of …, 2006 - academic.oup.com
Normal spermatogenesis is essential for reproduction and depends on proper spermatogonial
stem cell (SSC) function. Genes and signaling pathways that regulate SSC function have …
stem cell (SSC) function. Genes and signaling pathways that regulate SSC function have …
Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice
Peripheral polyneuropathy is a common and dose-limiting side effect of many important
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …
chemotherapeutic agents. Most such neuropathies are characterized by early axonal …
[PDF][PDF] Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy
A Viader, Y Sasaki, S Kim, A Strickland, CS Workman… - Neuron, 2013 - cell.com
Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has
been devoted to examining the role played by neuronal/axonal mitochondria, but how …
been devoted to examining the role played by neuronal/axonal mitochondria, but how …
Predictors of patient-assessed illness severity in irritable bowel syndrome
B Spiegel, A Strickland, BD Naliboff… - Official journal of the …, 2008 - journals.lww.com
BACKGROUND Conceptual models suggest that “irritable bowel syndrome (IBS) severity” is
a multidimensional outcome that is related to, yet distinct from, health-related quality of life (…
a multidimensional outcome that is related to, yet distinct from, health-related quality of life (…
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis
S Jain, CK Naughton, M Yang, A Strickland, K Vij… - 2004 - journals.biologists.com
The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived
neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. …
neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. …
[HTML][HTML] Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
AJ Bloom, X Mao, A Strickland, Y Sasaki… - Molecular …, 2022 - Springer
Background In response to injury, neurons activate a program of organized axon self-destruction
initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, …
initiated by the NAD + hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, …
[HTML][HTML] Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological
disorders is an active process driven by SARM1, an injury-activated NADase. Axons of …
disorders is an active process driven by SARM1, an injury-activated NADase. Axons of …
[HTML][HTML] A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model
Y Sato-Yamada, A Strickland, Y Sasaki… - The Journal of …, 2022 - Am Soc Clin Investig
Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …
mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial …
Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons
…, RA Barve, SE Maloney, A Strickland… - Journal of …, 2018 - Soc Neuroscience
CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates
gene expression by modifying 3D chromatin structure. Human mutations in CTCF cause …
gene expression by modifying 3D chromatin structure. Human mutations in CTCF cause …
Schwann cell O-GlcNAc glycosylation is required for myelin maintenance and axon integrity
S Kim, JC Maynard, Y Sasaki, A Strickland… - Journal of …, 2016 - Soc Neuroscience
Schwann cells (SCs), ensheathing glia of the peripheral nervous system, support axonal
survival and function. Abnormalities in SC metabolism affect their ability to provide this support …
survival and function. Abnormalities in SC metabolism affect their ability to provide this support …