[PDF][PDF] Dopamine-evoked synaptic regulation in the nucleus accumbens requires astrocyte activity

M Corkrum, A Covelo, J Lines, L Bellocchio… - Neuron, 2020 - cell.com
Dopamine is involved in physiological processes like learning and memory, motor control
and reward, and pathological conditions such as Parkinson's disease and addiction. In …

CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions

A Covelo, A Eraso-Pichot, I Fernandez-Moncada… - …, 2021 - Elsevier
The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly through
the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly expressed …

Gi/o protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

CA Durkee, A Covelo, J Lines, P Kofuji, J Aguilar… - Glia, 2019 - Wiley Online Library
G protein‐coupled receptors (GPCRs) play key roles in intercellular signaling in the brain.
Their effects on cellular function have been largely studied in neurons, but their functional …

[HTML][HTML] Dysregulation of astrocytic Ca2+ signaling and gliotransmitter release in mouse models of α-synucleinopathies

…, A Araque, P Kofuji, MK Lee, A Covelo - Acta …, 2023 - Springer
α-Synuclein is a major component of Lewy bodies (LB) and Lewy neurites (LN) appearing
in the postmortem brain of Parkinson's disease (PD) and other α-synucleinopathies. While …

[HTML][HTML] Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

B Singh, A Covelo, H Martell-Martínez… - Acta …, 2019 - Springer
Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically
and neuropathologically highly related α-synucleinopathies that collectively constitute the …

[PDF][PDF] Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration

R Serrat, A Covelo, V Kouskoff, S Delcasso… - Cell Reports, 2021 - cell.com
Intracellular calcium signaling underlies the astroglial control of synaptic transmission and
plasticity. Mitochondria-endoplasmic reticulum contacts (MERCs) are key determinants of …

Structural and functional plasticity of astrocyte processes and dendritic spine interactions

A Perez-Alvarez, M Navarrete, A Covelo… - Journal of …, 2014 - Soc Neuroscience
Experience-dependent plasticity of synaptic transmission, which represents the cellular
basis of learning, is accompanied by morphological changes in dendritic spines. Astrocytic …

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

A Covelo, A Araque - elife, 2018 - elifesciences.org
10.7554/eLife.32237.001 Accumulating evidence indicates that astrocytes are actively
involved in brain function by regulating synaptic activity and plasticity. Different gliotransmitters, …

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

G Perea, R Gómez, S Mederos, A Covelo… - Elife, 2016 - elifesciences.org
10.7554/eLife.20362.001 Interneurons are critical for proper neural network function and
can activate Ca 2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte …

Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission

…, M Navarrete, G Perea, A Covelo… - Cerebral …, 2015 - academic.oup.com
Endocannabinoids (eCBs) play key roles in brain function, acting as modulatory signals in
synaptic transmission and plasticity. They are recognized as retrograde messengers that …