User profiles for Andreas S. Thum

Andreas Thum

University of Leipzig
Verified email at uni-leipzig.de
Cited by 3057

The complete connectome of a learning and memory centre in an insect brain

…, JW Truman, CE Priebe, LF Abbott, AS Thum… - Nature, 2017 - nature.com
Associating stimuli with positive or negative reinforcement is essential for survival, but a
complete wiring diagram of a higher-order circuit supporting associative memory has not been …

[HTML][HTML] The neural substrate of spectral preference in Drosophila

…, CY Ting, S Huang, Z Lu, H Luan, J Rister, AS Thum… - Neuron, 2008 - cell.com
Drosophila vision is mediated by inputs from three types of photoreceptor neurons; R1–R6
mediate achromatic motion detection, while R7 and R8 constitute two chromatic channels. …

[HTML][HTML] The Role of Dopamine in Drosophila Larval Classical Olfactory Conditioning

M Selcho, D Pauls, KA Han, RF Stocker, AS Thum - PloS one, 2009 - journals.plos.org
Learning and memory is not an attribute of higher animals. Even Drosophila larvae are able
to form and recall an association of a given odor with an aversive or appetitive gustatory …

Recurrent architecture for adaptive regulation of learning in the insect brain

…, J Valdes-Aleman, T Ohyama, AS Thum… - Nature …, 2020 - nature.com
Dopaminergic neurons (DANs) drive learning across the animal kingdom, but the upstream
circuits that regulate their activity and thereby learning remain poorly understood. We …

[HTML][HTML] Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila

…, N Mancini, M Zlatic, JW Truman, AS Thum… - Nature …, 2018 - nature.com
The brain adaptively integrates present sensory input, past experience, and options for future
action. The insect mushroom body exemplifies how a central brain structure brings about …

Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin

…, N Gendre, RF Stocker, AS Thum - Journal of …, 2010 - Soc Neuroscience
Insect mushroom bodies are required for diverse behavioral functions, including odor
learning and memory. Using the numerically simple olfactory pathway of the Drosophila …

Multiple memory traces for olfactory reward learning in Drosophila

AS Thum, A Jenett, K Ito, M Heisenberg… - Journal of …, 2007 - Soc Neuroscience
Physical traces underlying simple memories can be confined to a single group of cells in the
brain. In the fly Drosophila melanogaster, the Kenyon cells of the mushroom bodies house …

[PDF][PDF] Four individually identified paired dopamine neurons signal reward in larval Drosophila

…, H Tanimoto, T Saumweber, B Gerber, AS Thum - Current Biology, 2016 - cell.com
Dopaminergic neurons serve multiple functions, including reinforcement processing during
associative learning [1–12]. It is thus warranted to understand which dopaminergic neurons …

The Role of octopamine and tyramine in Drosophila larval locomotion

…, B El Jundi, RF Stocker, AS Thum - Journal of …, 2012 - Wiley Online Library
The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic
waves of peristalsis and episodes of head swinging and turning. The two biogenic amines …

Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse

…, CH Liu, A Nikolaev, J Rister, AS Thum… - Journal of …, 2008 - Soc Neuroscience
Histamine (HA) is the photoreceptor neurotransmitter in arthropods, directly gating chloride
channels on large monopolar cells (LMCs), postsynaptic to photoreceptors in the lamina. …