User profiles for Andrew Gordus

Andrew Gordus

Assistant Professor of Biology, Johns Hopkins University
Verified email at jhu.edu
Cited by 6617

An optimized fluorescent probe for visualizing glutamate neurotransmission

…, L Tian, J Cichon, MT Harnett, J Akerboom, A Gordus… - Nature …, 2013 - nature.com
We describe an intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) with
signal-to-noise ratio and kinetics appropriate for in vivo imaging. We engineered iGluSnFR in …

[PDF][PDF] Feedback from network states generates variability in a probabilistic olfactory circuit

A Gordus, N Pokala, S Levy, SW Flavell, CI Bargmann - Cell, 2015 - cell.com
Variability is a prominent feature of behavior and is an active element of certain behavioral
strategies. To understand how neuronal circuits control variability, we examined the …

Optimization of a GCaMP calcium indicator for neural activity imaging

…, F Esposti, BG Borghuis, XR Sun, A Gordus… - Journal of …, 2012 - Soc Neuroscience
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience.
Recent efforts in protein engineering have significantly increased the performance of …

Sensitive red protein calcium indicators for imaging neural activity

H Dana, B Mohar, Y Sun, S Narayan, A Gordus… - elife, 2016 - elifesciences.org
10.7554/eLife.12727.001 Genetically encoded calcium indicators (GECIs) allow measurement
of activity in large populations of neurons and in small neuronal compartments, over times …

A quantitative protein interaction network for the ErbB receptors using protein microarrays

RB Jones, A Gordus, JA Krall, G MacBeath - Nature, 2006 - nature.com
Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate
one of the most well-studied signalling networks, there is not yet a genome-wide view of …

[HTML][HTML] Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

…, S Wabnig, M Prigge, J Tolö, A Gordus… - Frontiers in molecular …, 2013 - frontiersin.org
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience.
Here we describe red, single-wavelength GECIs, “RCaMPs,” engineered from circular …

Prevalence, distribution, and diversity of Salmonella enterica in a major produce region of California

…, MB Cooley, MT Jay-Russell, AG Gordus… - Applied and …, 2011 - Am Soc Microbiol
A survey was initiated to determine the prevalence of Salmonella enterica in the environment
in and around Monterey County, CA, a major agriculture region of the United States. …

Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels

N Pokala, Q Liu, A Gordus… - Proceedings of the …, 2014 - National Acad Sciences
Recent progress in neuroscience has been facilitated by tools for neuronal activation and
inactivation that are orthogonal to endogenous signaling systems. We describe here a …

Single-molecule transition-state analysis of RNA folding

…, VK Misra, MM Rhodes, A Gordus… - Proceedings of the …, 2003 - National Acad Sciences
How RNA molecules fold into functional structures is a problem of great significance given
the expanding list of essential cellular RNA enzymes and the increasing number of …

[PDF][PDF] A circuit for gradient climbing in C. elegans chemotaxis

J Larsch, SW Flavell, Q Liu, A Gordus, DR Albrecht… - Cell reports, 2015 - cell.com
Animals have a remarkable ability to track dynamic sensory information. For example, the
nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold …