Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases
SM Burm, EA Zuiderwijk-Sick, A EJ't Jong… - Journal of …, 2015 - Soc Neuroscience
Inflammasomes are multiprotein complexes that link pathogen recognition and cellular
stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas …
stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas …
[HTML][HTML] In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting
…, JM Janssen, J Liu, I Maggio, AEJ 't Jong… - Nature …, 2017 - nature.com
Precise genome editing involves homologous recombination between donor DNA and
chromosomal sequences subjected to double-stranded DNA breaks made by programmable …
chromosomal sequences subjected to double-stranded DNA breaks made by programmable …
[HTML][HTML] Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot
…, SM van Leeuwen, PR van den Berg, AEJ 't Jong… - Scientific reports, 2018 - nature.com
The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells.
This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 …
This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 …
Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia‐derived cues for maintenance of microglia identity
…, EA Zuiderwijk‐Sick, N Oosterhof, AEJ 't Jong… - Glia, 2022 - Wiley Online Library
Microglia are increasingly being recognized as druggable targets in neurodegenerative
disorders, and good in vitro models are crucial to address cell biological questions. Major …
disorders, and good in vitro models are crucial to address cell biological questions. Major …
Characterization of Laccases and Peroxidases from Wood-Rotting Fungi (Family Coprinaceae)
…, L Bech, T Halkier, P Schneider, T Anke - Applied and …, 1998 - Am Soc Microbiol
Panaeolus sphinctrinus, Panaeolus papilionaceus, and Coprinus friesii are described as
producers of ligninolytic enzymes. P. papilionaceus andP. sphinctrinus both produced a …
producers of ligninolytic enzymes. P. papilionaceus andP. sphinctrinus both produced a …
[HTML][HTML] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
…, RGJ Westendorp, GJ de Borst, PA de Jong… - The Lancet, 2015 - thelancet.com
Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…
A critical role for ethylene in hydrogen peroxide release during programmed cell death in tomato suspension cells
AJ de Jong, ET Yakimova, VM Kapchina, EJ Woltering - Planta, 2002 - Springer
Camptothecin, a topo isomerase-I inhibitor used in cancer therapy, induces apoptosis in animal
cells. In tomato (Lycopersicon esculentum Mill.) suspension cells, camptothecin induces …
cells. In tomato (Lycopersicon esculentum Mill.) suspension cells, camptothecin induces …
Chemical-induced apoptotic cell death in tomato cells: involvement of caspase-like proteases
AJ De Jong, FA Hoeberichts, ET Yakimova… - Planta, 2000 - Springer
A new system to study programmed cell death in plants is described. Tomato (Lycopersicon
esculentum Mill.) suspension cells were induced to undergo programmed cell death by …
esculentum Mill.) suspension cells were induced to undergo programmed cell death by …
[HTML][HTML] Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients
BACKGROUND. Cell-free circulating nucleic acids, including 22-nt microRNAs (miRNAs),
represent noninvasive biomarkers for treatment response monitoring of cancer patients. While …
represent noninvasive biomarkers for treatment response monitoring of cancer patients. While …
[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
…, J Cooper, J Palmen, W Spiering, PA De Jong… - Bmj, 2014 - bmj.com
… professor of preventative medicine10, Jackie Cooper senior research fellow61, Jutta
Palmen senior research fellow42, Wilko Spiering vascular medicine internist62, Pim A de Jong …
Palmen senior research fellow42, Wilko Spiering vascular medicine internist62, Pim A de Jong …