The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin …

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …

Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous brain-…

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence. …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein tangles
are key histopathological hallmarks of Alzheimer's disease (AD). This type of pathology …

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease
that shares several clinical and pathological features with Alzheimer's disease (AD), …

Neurodegenerative diseases are characterized by selective neuronal vulnerability and
neurodegeneration in specific brain regions. The pathogenesis of these disorders centrally …

J. Neurochem. (2011) 118, 460–474. Abstract AMP‐activated protein kinase (AMPK)
stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy …