D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role

A D'Aniello - Brain research reviews, 2007 - Elsevier
d-Aspartic acid (d-Asp), an endogenous amino acid present in vertebrates and invertebrates,
plays an important role in the neuroendocrine system, as well as in the development of the …

Occurrence of D‐aspartic acid and N‐methyl‐D‐aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth …

…, GH Fisher, A Milone, A Seleni, S D'Aniello… - The FASEB …, 2000 - Wiley Online Library
Using two specific and sensitive fluorometric/HPLC methods and a GC‐MS method, alone
and in combination with D‐aspartate oxidase, we have demonstrated for the first time that N‐…

[HTML][HTML] Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.

A D'Aniello, G D'Onofrio, M Pischetola… - Journal of Biological …, 1993 - Elsevier
D-Amino acids administered to animals are absorbed by the intestine and transported through
the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase …

Free D-aspartate and D-alanine in normal and Alzheimer brain

GH Fisher, A D'Aniello, A Vetere, L Padula… - Brain research …, 1991 - Elsevier
In this report we present evidence for the presence of free D-aspartic acid (D-Asp) and D-alanine
(D-Ala) in the white and gray matter of normal human brains and brains of individuals …

[HTML][HTML] The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

…, A Soricelli, A D'Aniello, S Ronsini, G D'Aniello - Reproductive Biology …, 2009 - Springer
Background D-aspartic acid is an amino acid present in neuroendocrine tissues of
invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this …

The Role of d-Aspartic Acid and N-Methyl-d-Aspartic Acid in the Regulation of Prolactin Release

G D'Aniello, A Tolino, A D'aniello, F Errico… - …, 2000 - academic.oup.com
In this study, using an enzymatic HPLC method in combination with d-aspartate oxidase, we
show that N-methyl-d-aspartate (NMDA) is present at nanomolar levels in rat nervous …

D‐Aspartic acid is a novel endogenous neurotransmitter

S D'Aniello, I Somorjai, J Garcia‐Fernŕndez… - The FASEB …, 2011 - Wiley Online Library
D‐Aspartic acid (D‐Asp) is present in invertebrate and vertebrate neuroendocrine tissues’
where it carries out important physiological functions and is implicated in nervous system …

Further study on the specificity of D-amino acid oxidase and D-aspartate oxidase and time course for complete oxidation of D-amino acids.

A D'Aniello, A Vetere, L Petrucelli - Comparative biochemistry and …, 1993 - europepmc.org
1. D-Amino acid oxidase (D-AAO) oxidizes: D-Met, D-Pro, D-Phe, D-Tyr, D-Ile, D-Leu, D-Ala
and D-Val. D-Ser, D-Arg, D-His, D-norleucine and D-Trp are oxidized at a low rate. D-…

D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801

…, E Topo, G Fisone, A D'Aniello… - Journal of …, 2008 - Soc Neuroscience
Since their discovery in the mammalian CNS, d-aspartate and d-serine have aroused a
strong interest with regard to their role as putative neuromodulatory molecules. Whereas the …

[HTML][HTML] Occurrence of D-aspartic acid in human seminal plasma and spermatozoa: possible role in reproduction

G D'Aniello, S Ronsini, F Guida, P Spinelli… - Fertility and sterility, 2005 - Elsevier
OBJECTIVE: To determine D-aspartic acid (D-Asp) in human seminal plasma and
spermatozoa in fertile and infertile donors. DESIGN: Prospective observation study. SETTING: …