In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …

The molecular mechanisms underlying the organization of ion channels and signaling
molecules at the synaptic junction are largely unknown. Recently, members of the PSD-95/SAP90 …

The mechanisms by which neurotransmitter receptors are immobilized at postsynaptic sites
in neurons are largely unknown. The activity of NMDA (N-methyl-D-aspartate) receptors is …

We describe here a novel effect of activity on the subcellular distribution of NMDA receptors
in hippocampal neurons in culture. In spontaneously active neurons, NMDA receptors were …

To determine their roles in the assembly of glutamatergic postsynaptic sites, we studied the
distributions of NMDA- and AMPA-type glutamate receptors; the NMDA receptor-interacting …

Objective: To determine the frequency and nature of leptomeningeal contrast enhancement
in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated …

The apical sodium-dependent bile acid transporter (Asbt) is responsible for transport across
the intestinal brush border membrane; however, the carrier(s) responsible for basolateral …

The liver can substantially regenerate after injury, with both main epithelial cell types,
hepatocytes and biliary epithelial cells (BECs), playing important roles in parenchymal …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
Western world, and safe and effective therapies are needed. Bile acids (BAs) and their …

Previous studies have led to the hypothesis that some proteins of the postsynaptic membrane
are locally synthesized at postsynaptic sites. To evaluate this hypothesis, synaptosome …