Mutations in human parkin have been identified in familial Parkinson's disease and in some
sporadic cases. Here, we report that expression of mutant but not wild-type human parkin in …

ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated
membrane protein (VAMP)-associated membrane protein B)/ALS8). We have …

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized
by selective death of motor neurons. In 5–10% of the familial cases, the disease is …

Mon1 is an evolutionarily conserved protein involved in the conversion of Rab5 positive early
endosomes to late endosomes through the recruitment of Rab7. We have identified a role …

Nutrient sensing and metabolic homeostasis play an important role in the proper growth
and development of an organism, and also in the energy intensive process of reproduction. …

A majority of neurons that form the ventral nerve cord send out long axons that cross the
midline through anterior or posterior commissures. A smaller fraction extend longitudinally and …

Monensin-sensitive 1 (Mon1) is an endocytic regulator that participates in the conversion of
Rab5-positive early endosomes to Rab7-positive late endosomes. In Drosophila, loss of …

Mutation in parkin and pink1 is associated with Parkinson’s disease (PD), the most common
movement disorder characterized by muscular dysfunction. In a previous study, we …

During gastrulation in Drosophila, ventral cells change shape, undergoing synchronous apical
constriction, to create the ventral furrow (VF). This process is affected in mutant embryos …

Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset, progressive motor neurodegenerative
disorder. A key pathological feature of the disease is the presence of heavily …