User profiles for Arthur Liesz

Arthur Liesz

Professor of Experimental Neurology, Institute for Stroke and Dementia Research, LMU …
Verified email at med.uni-muenchen.de
Cited by 9343

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

A Liesz, E Suri-Payer, C Veltkamp, H Doerr… - Nature medicine, 2009 - nature.com
Systemic and local inflammatory processes have a key, mainly detrimental role in the
pathophysiology of ischemic stroke. Currently, little is known about endogenous counterregulatory …

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

A Liesz, W Zhou, É Mracskó, S Karcher, H Bauer… - Brain, 2011 - academic.oup.com
T lymphocytes are increasingly recognized as key modulators of detrimental inflammatory
cascades in acute ischaemic stroke, but the potential of T cell-targeted therapy in brain …

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

…, AM Planas, N Plesnila, D Vivien, A Liesz - Science translational …, 2015 - science.org
Numerous treatments have been reported to provide a beneficial outcome in experimental
animal stroke models; however, these treatments (with the exception of tissue plasminogen …

Microbiota dysbiosis controls the neuroinflammatory response after stroke

…, D Garzetti, B Stecher, M Dichgans, A Liesz - Journal of …, 2016 - Soc Neuroscience
Acute brain ischemia induces a local neuroinflammatory reaction and alters peripheral
immune homeostasis at the same time. Recent evidence has suggested a key role of the gut …

Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection

…, N Wieczorek, T Giese, A Lorenz, G Auffarth, A Liesz… - Stroke, 2009 - Am Heart Assoc
Background and Purpose— Acute ischemic stroke in humans is associated with profound
alterations in the immune system. Hallmarks of this stroke-induced immunodepression …

Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke

A Liesz, W Zhou, SY Na, GJ Hämmerling… - Journal of …, 2013 - Soc Neuroscience
Inflammatory mechanisms contribute substantially to secondary tissue injury after brain
ischemia. Regulatory T cells (Tregs) are key endogenous modulators of postischemic …

Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models

W Zhou, A Liesz, H Bauer, C Sommer… - Brain …, 2013 - Wiley Online Library
Cellular and humoral inflammations play important roles in ischemic brain injury. The
effectiveness of immunomodulatory therapies may critically depend on the chosen experimental …

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

…, B Gesierich, M Duering, I Katona, A Liesz… - Science, 2020 - science.org
Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

[HTML][HTML] CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

…, R Martini, S Besson-Girard, S Kaji, A Liesz… - Nature …, 2022 - nature.com
A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present study…

Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran

W Zhou, S Schwarting, S Illanes, A Liesz, M Middelhoff… - Stroke, 2011 - Am Heart Assoc
Background and Purpose— Dabigatran-etexilate (DE) recently has been approved for stroke
prevention in atrial fibrillation. However, lack of effective antagonists represents a major …