User profiles for Austin J Cooney

Austin Cooney

The University of Texas at Austin Dell Medical School
Verified email at austin.utexas.edu
Cited by 13312

[HTML][HTML] Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation

…, NI Holter, D Riethmacher, G Schütz, AJ Cooney… - Cell, 2009 - cell.com
In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible
for triggering the indifferent gonads to develop as testes rather than ovaries. However, …

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

…, T Hämäläinen, SL Peng, ZJ Lan, AJ Cooney… - Science, 2008 - science.org
In the mammalian ovary, progressive activation of primordial follicles from the dormant pool
serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, …

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

…, P Gu, H Xin, SY Jung, J Qin, J Wong, AJ Cooney… - Nature cell …, 2008 - nature.com
Nanog and Oct4 are essential transcription factors that regulate self-renewal and pluripotency
of ES cells. However, the mechanisms by which Nanog and Oct4 modulate ES cell fate …

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal …

AJ Cooney, SY Tsai, BW O'Malley… - Molecular and cellular …, 1992 - Taylor & Francis
Alignment of natural chicken ovalbumin upstream promoter transcription factor (COUP-TF)
response elements shows that, in addition to the predominant direct repeat of the GGTCA …

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

…, N Gorre, T Hämäläinen, AJ Cooney… - Human molecular …, 2010 - academic.oup.com
To maintain the female reproductive lifespan, the majority of ovarian primordial follicles are
preserved in a quiescent state in order to provide ova for later reproductive life. However, the …

Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development

…, J Gossen, SA Kliewer, AJ Cooney - … and cellular biology, 2005 - Taylor & Francis
Oct4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic
stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and …

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

…, AJ Cooney, RB Lanz, FA Pereira, J Wu… - Genome …, 2004 - genome.cshlp.org
Completion of the Rattus norvegicus genome sequence enabled a global inventory and
analysis of the nuclear receptors (NRs) in three mammalian species. Forty-nine NR members …

Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice

ZJ Lan, X Xu, AJ Cooney - Biology of reproduction, 2004 - academic.oup.com
Oocyte-specific deletion of ovarian genes using Cre/loxP technology provides an excellent
tool to understand their physiological roles during folliculogenesis, oogenesis, and …

[PDF][PDF] Mouse germline restriction of Oct4 expression by germ cell nuclear factor

…, J Sutter, I Sylvester, HR Schöler, AJ Cooney - Developmental cell, 2001 - cell.com
The POU-domain transcription factor Oct4 is essential for the maintenance of the mammalian
germline. In this study, we show that the germ cell nuclear factor (GCNF), an orphan …

Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation

…, M Mancini, DA Wheeler, AJ Cooney - … and cellular biology, 2005 - Taylor & Francis
Embryonic stem (ES) cell pluripotency and differentiation are controlled by a network of
transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are …