User profiles for Austin J Cooney
Austin CooneyThe University of Texas at Austin Dell Medical School Verified email at austin.utexas.edu Cited by 13312 |
[HTML][HTML] Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible
for triggering the indifferent gonads to develop as testes rather than ovaries. However, …
for triggering the indifferent gonads to develop as testes rather than ovaries. However, …
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
In the mammalian ovary, progressive activation of primordial follicles from the dormant pool
serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, …
serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, …
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
Nanog and Oct4 are essential transcription factors that regulate self-renewal and pluripotency
of ES cells. However, the mechanisms by which Nanog and Oct4 modulate ES cell fate …
of ES cells. However, the mechanisms by which Nanog and Oct4 modulate ES cell fate …
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal …
AJ Cooney, SY Tsai, BW O'Malley… - Molecular and cellular …, 1992 - Taylor & Francis
Alignment of natural chicken ovalbumin upstream promoter transcription factor (COUP-TF)
response elements shows that, in addition to the predominant direct repeat of the GGTCA …
response elements shows that, in addition to the predominant direct repeat of the GGTCA …
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
…, N Gorre, T Hämäläinen, AJ Cooney… - Human molecular …, 2010 - academic.oup.com
To maintain the female reproductive lifespan, the majority of ovarian primordial follicles are
preserved in a quiescent state in order to provide ova for later reproductive life. However, the …
preserved in a quiescent state in order to provide ova for later reproductive life. However, the …
Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development
…, J Gossen, SA Kliewer, AJ Cooney - … and cellular biology, 2005 - Taylor & Francis
Oct4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic
stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and …
stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and …
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome
Completion of the Rattus norvegicus genome sequence enabled a global inventory and
analysis of the nuclear receptors (NRs) in three mammalian species. Forty-nine NR members …
analysis of the nuclear receptors (NRs) in three mammalian species. Forty-nine NR members …
Differential Oocyte-Specific Expression of Cre Recombinase Activity in GDF-9-iCre, Zp3cre, and Msx2Cre Transgenic Mice
ZJ Lan, X Xu, AJ Cooney - Biology of reproduction, 2004 - academic.oup.com
Oocyte-specific deletion of ovarian genes using Cre/loxP technology provides an excellent
tool to understand their physiological roles during folliculogenesis, oogenesis, and …
tool to understand their physiological roles during folliculogenesis, oogenesis, and …
[PDF][PDF] Mouse germline restriction of Oct4 expression by germ cell nuclear factor
…, J Sutter, I Sylvester, HR Schöler, AJ Cooney - Developmental cell, 2001 - cell.com
The POU-domain transcription factor Oct4 is essential for the maintenance of the mammalian
germline. In this study, we show that the germ cell nuclear factor (GCNF), an orphan …
germline. In this study, we show that the germ cell nuclear factor (GCNF), an orphan …
Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation
Embryonic stem (ES) cell pluripotency and differentiation are controlled by a network of
transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are …
transcription factors and signaling molecules. Transcription factors such as Oct4 and Nanog are …