The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Opioids have long been known to inhibit sexual behavior. However, it is only within the last
decade that the effects of opioids on sexual behavior have been studied extensively and a …

The endocannabinoid system is a widely distributed, neuromodulatory system which serves
an integral role in regulating synaptic transmission. The presence of this system in stress-…

Deficits in cognitive functioning and flexibility are seen following both chronic stress and
modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether …

Secretion of glucocorticoid hormones during stress produces an array of physiological changes
that are adaptive and beneficial in the short term. In the face of repeated stress exposure…

The mechanisms subserving the ability of glucocorticoid signaling within the medial
prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary–…

Central endocannabinoid signaling is known to be responsive to stressful stimuli; however,
there is no research to date characterizing the effects of stress on peripheral …

Endocannabinoids inhibit hypothalamic–pituitary–adrenal (HPA) axis activity; however, the
neural substrates and pathways subserving this effect are not well characterized. The …

Background: Preclinical research has suggested that the endocannabinoid system may be
involved in the etiology and/or treatment of depression; however, there are no published …

These experiments aimed to assess whether enhanced activity at the cannabinoid CB 1
receptor elicits antidepressant-like effects. To examine this we administered 1 and 5 mg/kg …