User profiles for B. T. Hyman

Bradley Hyman

Massachusetts General Hospital, Harvard Medical School
Verified email at partners.org
Cited by 201814

Neuropathological alterations in Alzheimer disease

…, E Masliah, BT Hyman - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

…, PR Hof, CM Hulette, BT Hyman… - … of Neuropathology & …, 2012 - academic.oup.com
Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Synergy between amyloid-β and tau in Alzheimer's disease

MA Busche, BT Hyman - Nature neuroscience, 2020 - nature.com
Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques
and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the …

An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

…, RL Buckner, AM Dale, RP Maguire, BT Hyman… - Neuroimage, 2006 - Elsevier
In this study, we have assessed the validity and reliability of an automated labeling system
that we have developed for subdividing the human cerebral cortex on magnetic resonance …

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic …

…, DS Knopman, H Chertkow, BT Hyman… - Alzheimer's & …, 2011 - Elsevier
The National Institute on Aging and the Alzheimer’s Association charged a workgroup with
the task of revising the 1984 criteria for Alzheimer’s disease (AD) dementia. The workgroup …

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

…, JH Growdon, ET Hedley-Whyte, BT Hyman - Neurology, 1992 - AAN Enterprises
… Arriagada P, Hyman BT. Predominance of A4 over Alz-50 positive plaques in non-… Arriagada
P, Hyman BT. Topographic distribution of Alzheimer neuronal changes in normal aging …

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

BT Hyman, GW Van Hoesen, AR Damasio, CL Barnes - Science, 1984 - science.org
Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular
pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the …

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

BT Hyman, CH Phelps, TG Beach, EH Bigio… - Alzheimer's & …, 2012 - Elsevier
A consensus panel from the United States and Europe was convened recently to update
and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's …

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease

…, JC Morris, JH Growdon, BT Hyman - Journal of …, 1996 - Soc Neuroscience
The entorhinal cortex (EC) plays a crucial role as a gateway connecting the neocortex and
the hippocampal formation. Layer II of the EC gives rise to the perforant pathway, the major …

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

…, DR Thal, JQ Trojanowski, HV Vinters, BT Hyman - Acta …, 2012 - Springer
We present a practical guide for the implementation of recently revised National Institute on
Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’…