Small-molecule probes can illuminate biological processes and aid in the assessment of
emerging therapeutic targets by perturbing biological systems in a manner distinct from other …

MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved small non-coding
RNAs that are thought to control gene expression by targeting mRNAs for degradation or …

Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …

Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex
organs. Despite this, the global landscape of intercellular signaling in mammalian liver has …

Background— Macrophage activation plays a crucial role in regulating adipose tissue
inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular …

Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

Presynaptic calcium channels play a central role in chemical synaptic transmission by
providing the calcium trigger for evoked neurotransmitter release. These voltage-gated calcium …

MicroRNAs (miRNAs) are a family of ≈22-nt noncoding RNAs that can posttranscriptionally
regulate gene expression. Several miRNAs are specifically expressed in hematopoietic cells…

The p53 transcription factor is a key tumor suppressor and a central regulator of the stress
response. To ensure a robust and precise response to cellular signals, p53 gene expression …

The article describes a readily easy adaptive in vitro model to investigate macrophage
polarization. In the presence of GM-CSF/M-CSF, hematopoietic stem/progenitor cells from the …