Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Depression is a polygenic and highly complex psychiatric disorder that remains a major burden
on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are …

The neurogenesis hypothesis of depression was originally formed upon the demonstration
that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work …

The serine/threonine kinase Cdk5 plays an essential role in neuronal positioning during
corticogenesis, but the underlying mechanisms are unknown. In nonneuronal cells, the tyrosine …

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the
mechanisms by which they influence behavior are only partially resolved. Adult hippocampal …

The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important
role in brain development; however, it is unclear how DISC1 is regulated during cortical …

Using in situ hybridization, we describe, for the first time, the profiles of expression of
serotonin receptors (Htr/5-HTR) along the dorsal–ventral axis of mouse hippocampus. cRNA …

The use of hyponeophagia, in which exposure to a novel environment suppresses feeding
behavior, has been used to assess anxiety-related behavior in animals for over seven …

Depression is a debilitating chronic illness that affects around 350 million people worldwide.
Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because …

Selective serotonin reuptake inhibitors are the mostly widely used treatment for major
depressive disorders and also are prescribed for several anxiety disorders. However, similar to …