[PDF][PDF] Ionic channels in excitable membranes. Current problems and biophysical approaches
B Hille - Biophysical journal, 1978 - cell.com
Ionic channels are gated aqueous pores whose conformational changes are driven by the
electric field in the membrane. Gating may be studied by three electrical methods: ionic …
electric field in the membrane. Gating may be studied by three electrical methods: ionic …
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
K Mackie, B Hille - Proceedings of the National Academy of …, 1992 - National Acad Sciences
The psychoactive properties of Cannabis sativa and its major biologically active constituent,
delta 9-tetrahydrocannabinol, have been known for years. The recent identification and …
delta 9-tetrahydrocannabinol, have been known for years. The recent identification and …
PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
BC Suh, B Hille - Annu. Rev. Biophys., 2008 - annualreviews.org
Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.
B Hille - The Journal of general physiology, 1977 - rupress.org
The properties of Na channels of the node of Ranvier are altered by neutral, amine, and
quaternary local anesthetic compounds. The kinetics of the Na currents are governed by a …
quaternary local anesthetic compounds. The kinetics of the Na currents are governed by a …
Modulation of ion-channel function by G-protein-coupled receptors
B Hille - Trends in neurosciences, 1994 - cell.com
Neurotransmitters acting through G-protein-coupled receptors change the electrical excitability
of neurons. Activation of receptors can affect the voltage dependence, the speed of gating…
of neurons. Activation of receptors can affect the voltage dependence, the speed of gating…
GTP-binding proteins couple cardiac muscarinic receptors to a K channel
…, JM Martin, DD Hunter, NM Nathanson, B Hille - Nature, 1985 - nature.com
Binding of acetylcholine (ACh) to cardiac muscarinic ACh receptors (mAChR) activates a
potassium channel that slows pacemaker activity 1–3 . Although the time course of this …
potassium channel that slows pacemaker activity 1–3 . Although the time course of this …
The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion
B Hille - The Journal of general physiology, 1967 - rupress.org
The effect of tetraethylammonium ion (TEA) on the voltage clamp currents of nodes of Ranvier
of frog myelinated nerve fibers is studied. The delayed K currents can be totally abolished …
of frog myelinated nerve fibers is studied. The delayed K currents can be totally abolished …
Modulation of Ca2+ channels by G-protein beta gamma subunits.
S Herlitze, DE Garcia, K Mackie, B Hille, T Scheuer… - Nature, 1996 - europepmc.org
Calcium ions entering cells through voltage-gated Ca2+ channels initiate rapid release of
neurotransmitters and secretion of hormones. Ca2+ currents can be inhibited in many cell …
neurotransmitters and secretion of hormones. Ca2+ currents can be inhibited in many cell …
Potassium channels as multi-ion single-file pores.
B Hille, W Schwarz - The Journal of general physiology, 1978 - rupress.org
A literature review reveals many lines of evidence that both delayed rectifier and inward rectifier
potassium channels are multi-ion pores. These include unidirectional flux ratios given by …
potassium channels are multi-ion pores. These include unidirectional flux ratios given by …
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
…, JB Jensen, HY Chen, HC Lu, B Hille… - Proceedings of the …, 2008 - National Acad Sciences
The CB 1 cannabinoid receptor mediates many of the psychoactive effects of Δ 9 THC, the
principal active component of cannabis. However, ample evidence suggests that additional …
principal active component of cannabis. However, ample evidence suggests that additional …