[PDF][PDF] Ionic channels in excitable membranes. Current problems and biophysical approaches

B Hille - Biophysical journal, 1978 - cell.com
Ionic channels are gated aqueous pores whose conformational changes are driven by the
electric field in the membrane. Gating may be studied by three electrical methods: ionic …

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

K Mackie, B Hille - Proceedings of the National Academy of …, 1992 - National Acad Sciences
The psychoactive properties of Cannabis sativa and its major biologically active constituent,
delta 9-tetrahydrocannabinol, have been known for years. The recent identification and …

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

BC Suh, B Hille - Annu. Rev. Biophys., 2008 - annualreviews.org
Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require …

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

B Hille - The Journal of general physiology, 1977 - rupress.org
The properties of Na channels of the node of Ranvier are altered by neutral, amine, and
quaternary local anesthetic compounds. The kinetics of the Na currents are governed by a …

Modulation of ion-channel function by G-protein-coupled receptors

B Hille - Trends in neurosciences, 1994 - cell.com
Neurotransmitters acting through G-protein-coupled receptors change the electrical excitability
of neurons. Activation of receptors can affect the voltage dependence, the speed of gating…

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

…, JM Martin, DD Hunter, NM Nathanson, B Hille - Nature, 1985 - nature.com
Binding of acetylcholine (ACh) to cardiac muscarinic ACh receptors (mAChR) activates a
potassium channel that slows pacemaker activity 1–3 . Although the time course of this …

The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion

B Hille - The Journal of general physiology, 1967 - rupress.org
The effect of tetraethylammonium ion (TEA) on the voltage clamp currents of nodes of Ranvier
of frog myelinated nerve fibers is studied. The delayed K currents can be totally abolished …

Modulation of Ca2+ channels by G-protein beta gamma subunits.

S Herlitze, DE Garcia, K Mackie, B Hille, T Scheuer… - Nature, 1996 - europepmc.org
Calcium ions entering cells through voltage-gated Ca2+ channels initiate rapid release of
neurotransmitters and secretion of hormones. Ca2+ currents can be inhibited in many cell …

Potassium channels as multi-ion single-file pores.

B Hille, W Schwarz - The Journal of general physiology, 1978 - rupress.org
A literature review reveals many lines of evidence that both delayed rectifier and inward rectifier
potassium channels are multi-ion pores. These include unidirectional flux ratios given by …

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

…, JB Jensen, HY Chen, HC Lu, B Hille… - Proceedings of the …, 2008 - National Acad Sciences
The CB 1 cannabinoid receptor mediates many of the psychoactive effects of Δ 9 THC, the
principal active component of cannabis. However, ample evidence suggests that additional …