Betahistine in the treatment of Ménière's disease

…, M Novotny, B Tighilet - … disease and treatment, 2007 - Taylor & Francis
Ménière’s disease and related disease of the vestibular system are common and debilitating.
Current therapy is multi-modal and includes drug therapy and lifestyle adaptations. …

Betahistine dihydrochloride treatment facilitates vestibular compensation in the cat

B Tighilet, J Leonard, M Lacour - Journal of vestibular …, 1995 - content.iospress.com
Unilateral lesion of the vestibular system induces posturo-locomotor deficits that are
compensated for with time. Drug therapy is currently used to improve the recovery process and to …

The balance of sleep: role of the vestibular sensory system

S Besnard, B Tighilet, C Chabbert, M Hitier… - Sleep medicine …, 2018 - Elsevier
The vestibular system encodes linear and angular head motion supporting numerous
functions from gaze stabilization and postural control, to high-level cortical functions involving …

New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat

B Tighilet, JM Brezun, G Dit Duflo Sylvie… - European Journal of …, 2007 - Wiley Online Library
Recent findings revealed a reactive neurogenesis after lesions and in several models of
disease. After unilateral vestibular neurectomy (UVN), we previously reported γ‐aminobutyric …

Tell me your vestibular deficit, and I'll tell you how you'll compensate

M Lacour, S Dutheil, B Tighilet… - Annals of the New …, 2009 - Wiley Online Library
Most patients with unilateral vestibular loss exhibit a similar static and dynamic vestibular
syndrome consisting of vestibulo‐ocular, posturolocomotor, and perceptive deficits. This …

[HTML][HTML] Betahistine treatment in a cat model of vestibular pathology: pharmacokinetic and pharmacodynamic approaches

B Tighilet, J Léonard, I Watabe… - Frontiers in …, 2018 - frontiersin.org
This study is a pharmacokinetic (PK) and pharmacodynamics (PD) approach using betahistine
doses levels in unilateral vestibular neurectomized cats (UVN) comparable to those used …

Adult neurogenesis promotes balance recovery after vestibular loss

B Tighilet, C Chabbert - Progress in Neurobiology, 2019 - Elsevier
A phenomenon called vestibular compensation occurs after peripheral vestibular loss. This
process involves a mosaic of profound structural rearrangements within the vestibular nuclei. …

[HTML][HTML] Quantitative evaluation of a new posturo-locomotor phenotype in a rodent model of acute unilateral vestibulopathy

…, O Dumas, C Chabbert, B Tighilet - Frontiers in …, 2020 - frontiersin.org
Vestibular pathologies are difficult to diagnose. Existing devices make it possible to quantify
and follow the evolution of posturo-locomotor symptoms following vestibular loss in static …

[HTML][HTML] Sensorimotor rehabilitation promotes vestibular compensation in a rodent model of acute peripheral vestibulopathy by promoting microgliogenesis in the …

…, F Xavier, O Dumas, C Chabbert, V Artzner, B Tighilet - Cells, 2021 - mdpi.com
Acute peripheral vestibulopathy leads to a cascade of symptoms involving balance and gait
disorders that are particularly disabling for vestibular patients. Vestibular rehabilitation …

Comparative analysis of pharmacological treatments with N-acetyl-DL-leucine (Tanganil) and its two isomers (N-acetyl-L-leucine and N-acetyl-D-leucine) on …

B Tighilet, J Leonard, L Bernard-Demanze… - European Journal of …, 2015 - Elsevier
Head roll tilt, postural imbalance and spontaneous nystagmus are the main static vestibular
deficits observed after an acute unilateral vestibular loss (UVL). In the UVL cat model, these …