Endocannabinoid (eCB) signaling has been heavily implicated in the modulation of anxiety
and depressive behaviors and emotional learning. However, the role of the most-abundant …

Learning and memory is widely believed to result from changes in connectivity within neuronal
circuits due to synaptic plasticity. Work over the past two decades has shown that Ca 2 + …

Stress is a ubiquitous risk factor for the exacerbation and development of affective disorders
including major depression and posttraumatic stress disorder. Understanding the …

Augmentation of endogenous cannabinoid (eCB) signaling represents an emerging
approach to the treatment of affective disorders. Cyclooxygenase-2 (COX-2) oxygenates …

Characterizing the functional impact of novel mutations linked to autism spectrum disorder (ASD)
provides a deeper mechanistic understanding of the underlying pathophysiological …

To better understand the role of insulin signaling in the development of Alzheimer's disease
(AD), we utilized an animal model (intracerebroventricular injection of streptozotocin—ic-…

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates activity-dependent depression
of excitatory neurotransmission at central synapses, but the molecular regulation of 2-AG …

Ca 2+ /calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …

Background Endocannabinoid signaling plays an important role in regulating synaptic
transmission in the striatum, a brain region implicated as a central node of dysfunction in autism …

The brains of Alzheimer's disease (AD) patients have large numbers of plaques that contain
amyloid beta (Aβ) peptides which are believed to play a pivotal role in AD pathology. …