Cognitive abilities, such as volitional attention, operate under top-down, executive frontal
cortical control of hierarchically lower structures. The circuit mechanisms underlying this …

Psychedelic drugs, including the serotonin 2a (5-HT 2A ) receptor partial agonist psilocybin,
are receiving renewed attention for their possible efficacy in treating a variety of …

Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors,
and its release dynamics have traditionally been linked to changes in midbrain dopamine …

A high-throughput, retrovirus-mediated mutagenesis method based on gene trapping in
embryonic stem cells was used to identify a novel mouse gene. The human ortholog encodes a …

The claustrum is a prominent but ill-defined forebrain structure that has been suggested to
integrate multisensory information and perhaps transform percepts into consciousness. The …

The dorsolateral striatum and cannabinoid type 1 receptor (CB1) signaling mediate habitual
action learning, which is thought to require a balance of activity in the direct and indirect …

The claustrum is among the most enigmatic of all prominent mammalian brain structures.
Since the 19th century, a wealth of data has amassed on this forebrain nucleus. However, …

The striatum has important roles in motor control and action learning and, like many brain
regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation …

Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an
important mechanism for the regulation of information storage and the control of actions, as …