Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode

C Seo, A Guru, M Jin, B Ito, BJ Sleezer, YY Ho, E Wang… - Science, 2019 - science.org
Survival depends on the selection of behaviors adaptive for the current environment. For
example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is …

[HTML][HTML] Signatures of value comparison in ventral striatum neurons

CE Strait, BJ Sleezer, BY Hayden - PLoS biology, 2015 - journals.plos.org
The ventral striatum (VS), like its cortical afferents, is closely associated with processing of
rewards, but the relative contributions of striatal and cortical reward systems remains unclear. …

Neuronal selectivity for spatial positions of offers and choices in five reward regions

CE Strait, BJ Sleezer, TC Blanchard… - Journal of …, 2016 - journals.physiology.org
When we evaluate an option, how is the neural representation of its value linked to information
that identifies it, such as its position in space? We hypothesized that value information …

Rule encoding in orbitofrontal cortex and striatum guides selection

BJ Sleezer, MD Castagno, BY Hayden - Journal of Neuroscience, 2016 - Soc Neuroscience
Active maintenance of rules, like other executive functions, is often thought to be the domain
of a discrete executive system. An alternative view is that rule maintenance is a broadly …

[HTML][HTML] Tonic exploration governs both flexibility and lapses

RB Ebitz, BJ Sleezer, HP Jedema… - PLoS computational …, 2019 - journals.plos.org
In many cognitive tasks, lapses (spontaneous errors) are tacitly dismissed as the result of
nuisance processes like sensorimotor noise, fatigue, or disengagement. However, some …

Robust encoding of spatial information in orbitofrontal cortex and striatum

SBM Yoo, BJ Sleezer, BY Hayden - Journal of cognitive neuroscience, 2018 - direct.mit.edu
Knowing whether core reward regions carry information about the positions of relevant
objects is crucial for adjudicating between choice models. One limitation of previous studies, …

Differential contributions of ventral and dorsal striatum to early and late phases of cognitive set reconfiguration

BJ Sleezer, BY Hayden - Journal of cognitive neuroscience, 2016 - direct.mit.edu
Flexible decision-making, a defining feature of human cognition, is typically thought of as a
canonical pFC function. Recent work suggests that the striatum may participate as well; …

Neuronal responses support a role for orbitofrontal cortex in cognitive set reconfiguration

BJ Sleezer, GA LoConte, MD Castagno… - European Journal of …, 2017 - Wiley Online Library
We are often faced with the need to abandon no‐longer beneficial rules and adopt new
ones. This process, known as cognitive set reconfiguration, is a hallmark of executive control. …

Irrational choices via a curvilinear representational geometry for value

K Jurewicz, BJ Sleezer, PS Mehta, BY Hayden… - bioRxiv, 2022 - biorxiv.org
We make decisions by comparing values, but how is value represented in the brain? Many
models assume, if only implicitly, that the representational geometry of value is linear. …

Tonic activity in lateral habenula neurons promotes disengagement from reward-seeking behavior

BJ Sleezer, RJ Post, DA Bulkin, RB Ebitz, V Lee, K Han… - bioRxiv, 2021 - biorxiv.org
Survival requires both the ability to persistently pursue goals and the ability to determine
when it is time to stop, an adaptive balance of perseverance and disengagement. Neural …