User profiles for Bridget M. Lumb
Bridget M LumbUniversity of Bristol Verified email at bristol.ac.uk Cited by 4543 |
A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
…, KK Tochiki, SA Stuart, JL Leith, BM Lumb… - Journal of …, 2009 - Soc Neuroscience
Translational control through the mammalian target of rapamycin (mTOR) is critical for
synaptic plasticity, cell growth, and axon guidance. Recently, it was also shown that mTOR …
synaptic plasticity, cell growth, and axon guidance. Recently, it was also shown that mTOR …
Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats
…, AG Teschemacher, H Furue, BM Lumb… - Journal of …, 2014 - Soc Neuroscience
Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …
[HTML][HTML] Local translation in primary afferent fibers regulates nociception
…, AK Sivasubramaniam, A Sheasby, BM Lumb… - PloS one, 2008 - journals.plos.org
Recent studies have demonstrated the importance of local protein synthesis for neuronal
plasticity. In particular, local mRNA translation through the mammalian target of rapamycin (…
plasticity. In particular, local mRNA translation through the mammalian target of rapamycin (…
Neural substrates underlying fear‐evoked freezing: the periaqueductal grey–cerebellar link
…, EV Earl, JL Leith, TC Watson, BM Lumb… - The Journal of …, 2014 - Wiley Online Library
Key points At the heart of the brain circuitry underlying fear behaviour is the periaqueductal
grey (PAG). We address an important gap in understanding regarding the neural pathways …
grey (PAG). We address an important gap in understanding regarding the neural pathways …
Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice
The management of neuropathic pain is unsatisfactory, and new treatments are required.
Because the sensitivity of a subset of fast-conducting primary afferent nociceptors is thought to …
Because the sensitivity of a subset of fast-conducting primary afferent nociceptors is thought to …
[HTML][HTML] Neural correlates of fear in the periaqueductal gray
TC Watson, NL Cerminara, BM Lumb… - Journal of …, 2016 - Soc Neuroscience
The dorsal and ventral periaqueductal gray (dPAG and vPAG, respectively) are embedded
in distinct survival networks that coordinate, respectively, innate and conditioned fear-evoked …
in distinct survival networks that coordinate, respectively, innate and conditioned fear-evoked …
Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour
The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the
identification of neurons in male rat ventrolateral PAG (vlPAG) that encode fear memory through …
identification of neurons in male rat ventrolateral PAG (vlPAG) that encode fear memory through …
The periaqueductal gray orchestrates sensory and motor circuits at multiple levels of the neuraxis
…, CL Lawrenson, R Apps, BM Lumb - Journal of …, 2015 - Soc Neuroscience
The periaqueductal gray (PAG) coordinates behaviors essential to survival, including striking
changes in movement and posture (eg, escape behaviors in response to noxious stimuli vs …
changes in movement and posture (eg, escape behaviors in response to noxious stimuli vs …
Inescapable and Escapable Pain is Represented in Distinct Hypothalamic‐Midbrain Circuits: Specific Roles for aδ‐and C‐Nociceptors
BM Lumb - Experimental physiology, 2002 - Wiley Online Library
The affective responses to pain arising from deep somatic and visceral tissues differ markedly
from those evoked by brief cutaneous insults. Deep pain evokes passive emotional coping …
from those evoked by brief cutaneous insults. Deep pain evokes passive emotional coping …
Top down control of spinal sensorimotor circuits essential for survival
S Koutsikou, R Apps, BM Lumb - The Journal of Physiology, 2017 - Wiley Online Library
The ability to interact with challenging environments requires coordination of sensory and
motor systems that underpin appropriate survival behaviours. All animals, including humans, …
motor systems that underpin appropriate survival behaviours. All animals, including humans, …