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Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity
and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein …

Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of
antiphospholipid antibodies, including anti–β2-glycoprotein-1 autoantibodies (anti-β2GP1) …

Blood coagulation is a host defense system that assists in maintaining the integrity of the
closed, high-pressure mammalian circulatory system after blood vessel injury. After initiation of …

PADGEM (platelet activation dependent granule-external membrane protein) is an integral
membrane protein of the alpha granules of platelets and Weibel-Palade bodies of endothelial …

THE glycoprotein P-selectin is a cell adhesion molecule of stimulated platelets and endothelial
cells, which mediates the interaction of these cells with neutrophils and monocytes 1,2 . It …

Using a laser-induced endothelial injury model, we examined thrombus formation in the
microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy to …

The initial adhesive interactions between circulating leukocytes and endothelia are mediated,
in part, by P-selectin. We now report the expression cloning of a functional iigand for P-…

We have used confocal and widefield microscopy to image thrombus formation in real time
in the microcirculation of a living mouse. This system provides high-speed, near-…

We detected des-γ-carboxy prothrombin, an abnormal prothrombin, in the serum of 69 of 76
patients (91 per cent) with biopsy-confirmed hepatocellular carcinoma (the mean level of the …