Two proteins previously known as Na + -dependent phosphate transporters have been
identified recently as vesicular glutamate transporters (VGLUT1 and VGLUT2). Together, …

Before their exocytotic release during stimulation of nerve terminals, nonpeptide neurotransmitters
are loaded into synaptic vesicles by specific transporters. Recently, a protein initially …

The unc-47 locus of Caenorhabditis elegans has been suggested to encode a synaptic
vesicle GABA transporter. Here we used hydropathy plot analysis to identify a candidate …

Cystinosis is an inherited lysosomal storage disease characterized by defective transport of
cystine out of lysosomes. However, the causative gene, CTNS, encodes a seven …

In eukaryotic cells, lysosomes represent a major site for macromolecule degradation.
Hydrolysis products are eventually exported from this acidic organelle into the cytosol through …

Three subtypes of vesicular transporters accumulate glutamate into synaptic vesicles to
promote its vesicular release. One of the subtypes, VGLUT3, is expressed in neurons, including …

Lysosomes are membrane-bound endocytic organelles that play a major role in degrading
cell macromolecules and recycling their building blocks. A comprehensive knowledge of the …

Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member of
a family of heptahelical membrane proteins related to bacteriorhodopsin and characterized …

Vitamin B 12 (cobalamin) is essential in animals for metabolism of branched chain amino
acids and odd chain fatty acids, and for remethylation of homocysteine to methionine 1 . In the …

The characterization of the Caenorhabditis elegans unc-47 gene recently allowed the
identification of a mammalian γ-amino butyric acid (GABA) transporter, presumed to be located in …