Cannabinoid co-administration may enable reduced opioid doses for analgesia. This updated
systematic review on the opioid-sparing effects of cannabinoids considered preclinical …

The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the
pathogenesis of Alzheimer’s disease (AD). However, how these oligomers might first impair …

Although muscarinic acetylcholine receptors (mAChRs) and NMDA receptors (NMDARs) are
important for synaptic plasticity, learning and memory, the manner in which they interact is …

Fear and emotional learning are modulated by endogenous opioids but the cellular basis
for this is unknown. The intercalated cells (ITCs) gate amygdala output and thus regulate the …

The endogenous cannabinoid transmitter system regulates synaptic transmission throughout
the nervous system. Unlike conventional transmitters, specific stimuli induce synthesis of …

The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol (THC)
and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …

(1) Background: The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), synergistically reduce allodynia in various …

The midbrain periaqueductal gray (PAG) plays a central role in pain modulation via
descending pathways. Opioids and cannabinoids are thought to activate these descending …

Background and Purpose The midbrain periaqueductal grey (PAG) plays a central role in
modulating pain through a descending pathway that projects indirectly to the spinal cord via …

Basolateral amygdala (BLA) is critical for fear learning, and its heightened activation is widely
thought to underpin a variety of anxiety disorders. Here we used chemogenetic techniques …