The sprouting of neurites, which will later become axons and dendrites, is an important
event in early neuronal differentiation. Studies in living neurons indicate that neuritogenesis …

Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …

… Because changes in growth cone activity and membrane flow in the putative axon are
temporally closely spaced (F Bradke, C Dotti, unpublished data), we cannot determine whether …

By the end of the first week in culture, hippocampal neurons have established a single axon
and several dendrites. These 2 classes of processes differ in their morphology, in their …

… medium) at 5% CO 2 and 36.5C. The proliferation of nonneuronal cells was prevented by …
After a centrifugation for 3 hr at 4C and 50,000 rpm in a TL-100 ultracentrifuge (Beckman), …

The Alzheimer amyloid precursor protein (APP) is cleaved by several proteases, the most
studied, but still unidentified ones, are those involved in the release of a fragment of APP, the …

The role of localized instability of the actin network in specifying axonal fate was examined
with the use of rat hippocampal neurons in culture. During normal neuronal development, …

The presynaptic protein α-synuclein has been implicated in the pathogenesis of Parkinson's
disease. First, two missense mutations A30P and A53T cause inheritable early onset …

Studies of the developing trophectoderm in the mouse embryo have shown that extensive
cellular remodeling occurs during epithelial formation. In this investigation, confocal …

… and right rows show the specific staining for profilin II (b and c) and dynamin I (e and f). The
right row shows a process at higher magnification (c, f and i). Co‐localization of profilin II and …