WE have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis
elegans hermaphrodites to live more than twice as long as wild type. This lifespan …

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live
for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, …

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues …

… The neurons of old, decrepit C. elegans show little signs of age ( … This pathway was
first linked to life span in C. elegans, where mutations in daf-2, a known regulatory gene ( …

… In this study 62 , this mutant grew to adulthood much more slowly than others have
observed at 20 C (refs 39, 40), suggesting that it was behaving as a class 2 allele, and thus …

… We thank all members of the Kenyon lab for critical review and discussion of this work. AD
was supported by the Cancer Research Fund of the Damon Runyon Foundation Fellowship, …

… Parents were fed ins-7 RNAi bacteria at 20 C; their progeny were moved to 22.5 C as eggs
… We thank all the members of the Kenyon laboratory, as well as Z. Gitai, for critical review and …

A 45 nm logic technology is described that for the first time incorporates high-k + metal gate
transistors in a high volume manufacturing process. The transistors feature 1.0 nm EOT high-…

… Previously, we showed that reducing the activity of C. elegans HSF-1 causes a rapid-aging
phenotype and shortens life-span (4). Conversely, we found that animals carrying additional …

A 22nm generation logic technology is described incorporating fully-depleted tri-gate
transistors for the first time. These transistors feature a 3 rd -generation high-k + metal-gate …