Glutamate receptors convey most of the fast excitatory transmission in the vertebrate central
nervous system (CNS). In addition, they appear to be crucially involved in plastic synaptic …

… Early evidence for the existence of functional presynaptic iGluRs was based on the ability
of exogenously applied KAR agonists to depolarize dorsal root C-fibres 1 , modulate …

Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to
induce behavioral and electrophysiological seizures as well as neuropathological lesions …

The effects of depriving thalamic relay and intralaminar nuclei from their reticularis thalami (RE)
inputs were investigated in acute and chronic experiments on cat. In acutely prepared …

A VARIETY of ligand-gated ion channels undergo a fast activation process after the rapid
application of agonist and also a slower transition towards desensitized or inactivated closed …

… The top and bottom band represent nonspecific crossreactivity of the secondary antibody,
as shown in the control lane C using wild-type extract without primary antibody. c,Receptor …

… , overnight, 4 C). The presence of the CB 1 in mitochondrial fractions was analyzed using
an antiserum directed against the C terminus of the receptor (Cayman, overnight, 4 C). Then …

The physiological conditions under which adenosine A 2A receptors modulate synaptic
transmission are presently unclear. We show that A 2A receptors are localized postsynaptically …

Two decades have passed since the first report of the cloning of a kainate-type glutamate
receptor (KAR) subunit. The intervening years have seen a rapid growth in our understanding …

… Two other successive transmembrane domains are connected by an extracellular loop and
are followed by an intracellular sequence containing the C-terminus. Recent crystallographic …