… In this article, Tony Altar discusses how existing treatments of depression might work by
increasing endogenous brain levels of BDNF or NT-3, which in turn could promote monoamine-…

… CA Altar, unpubhshed observahons) Thls contrasts with the ~mpa~rment of 5-HT neurons
seen in Alzhefmer's dlsease Gwen the rapld pace of recent developments Jn neurotrophm …

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical
roles in the survival, growth, and maintenance of brain and peripheral neurons. We report …

The role of neurotrophins as target-derived proteins that promote neuron survival following
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …

Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy}-3,4-dihydro-2(1H)-quinolinone,
a novel antipsychotic with partial agonist activity at dopamine D2 receptors, bound with …

… an intraperitoneal injection of 149 mg/kg chlorohydrate and 30.8 mg/kg sodium pentobarbital
and mounted in a small animal stereotaxic apparatus (David Kopf Instruments, Tijunga, CA)…

Objective This literature review assessed the burden of treatment-resistant depression in
the United States by compiling published data about the clinical, societal, and economic …

… The expression of BDNF was up‐regulated by elevation of intracellular cAMP and down‐regulated
by Ca 2+ ionophore, bovine brain extract and laminar fluid shear stress. These …

Vascular endothelial growth factor (VEGF) is a secreted heparin-binding mitogen; its growth-promoting
activity is limited to vascular endothelial cells in vitro and VEGF also stimulates …

Patients with schizophrenia often fail to respond to an initial course of therapy. This study
systematically reviewed the societal and economic burden of treatment-resistant schizophrenia …