Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
CJ Thiele, CP Reynolds, MA Israel - Nature, 1985 - nature.com
Proto-oncogenes may be important in the cellular processes central for the growth and
differentiation of normal cells 1,2 . N-myc is a DNA sequence which shares limited homology to …
differentiation of normal cells 1,2 . N-myc is a DNA sequence which shares limited homology to …
Glycogen synthase kinase 3β (GSK3β) mediates 6‐hydroxydopamine‐induced neuronal death
The causes of sporadic Parkinson's disease (PD) are poorly understood. 6‐Hydroxydopamine
(6‐ OHDA), a PD mimetic, is widely used to model this neurodegenerative disorder in vitro …
(6‐ OHDA), a PD mimetic, is widely used to model this neurodegenerative disorder in vitro …
[HTML][HTML] Adrenomedullin expression in human tumor cell lines Its potential role as an autocrine growth factor
MJ Miller, A Martínez, EJ Unsworth, CJ Thiele… - Journal of Biological …, 1996 - ASBMB
Although adrenomedullin (AM) previously has been identified in human tumors, its role has
remained elusive. Analysis by reverse transcriptase-polymerase chain reaction (RT-PCR) …
remained elusive. Analysis by reverse transcriptase-polymerase chain reaction (RT-PCR) …
The MYCN oncogene is a direct target of miR-34a
…, QR Chen, ATC Cheuk, P Tsang, Q Zhang, CJ Thiele… - Oncogene, 2008 - nature.com
Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma
tumors, and both are associated with an aggressive phenotype. Database searches identified …
tumors, and both are associated with an aggressive phenotype. Database searches identified …
[HTML][HTML] Microplastics in fish and fishmeal: an emerging environmental challenge?
Microplastics are contaminants of emerging concern; they are ingested by marine biota.
About a quarter of global marine fish landings is used to produce fishmeal for animal and …
About a quarter of global marine fish landings is used to produce fishmeal for animal and …
MS-27-275, an Inhibitor of Histone Deacetylase, Has Marked in Vitro and in Vivo Antitumor Activity against Pediatric Solid Tumors
… Khanna C., Jaboin J., Drakos E., Tsokos M., Thiele CJ Characterization of five orthotopic
xenograft model of neuroblastoma; primary adrenal tumor growth and spontaneous distant …
xenograft model of neuroblastoma; primary adrenal tumor growth and spontaneous distant …
On Trk—The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology
CJ Thiele, Z Li, AE McKee - Clinical cancer research, 2009 - AACR
In the beginning, Trk was an oncogene. Yet Neurotrophin-Trk signaling came to preeminence
in the field of neurobiology. Now it is appreciated that Trks regulate important processes in …
in the field of neurobiology. Now it is appreciated that Trks regulate important processes in …
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
…, YH Im, J Chang, SG Choi, PHB Sorensen, CJ Thiele… - Nature …, 1999 - nature.com
Chromosomal translocations resulting in the expression of chimaeric transcription factors
are frequently observed in tumour cells 1, and have been suggested to be a common …
are frequently observed in tumour cells 1, and have been suggested to be a common …
Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway
… Kaplan DR, Matsumoto K., Lucarelli E., Thiele CJ Induction of TrkB by retinoic acid
mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. …
mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. …
[HTML][HTML] Evaluation of existing methods to extract microplastics from bivalve tissue: Adapted KOH digestion protocol improves filtration at single-digit pore size
Methods standardisation in microplastics research is needed. Apart from reagent-dependent
effects on microplastics, varying target particle sizes can hinder result comparison between …
effects on microplastics, varying target particle sizes can hinder result comparison between …