Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
A Selective, Hydrogel‐Based Prodrug Delivery System Efficiently Activates a Suicide Gene to Remove Undifferentiated Human Stem Cells Within Neural Grafts
…, ZE Zadeh, RJ Williams, CPJ Hunt… - Advanced Functional …, 2023 - Wiley Online Library
The directed differentiation of human pluripotent stem cells (hPSCs) into defined populations
has advanced regenerative medicine, especially for Parkinson's disease where clinical …
has advanced regenerative medicine, especially for Parkinson's disease where clinical …
[PDF][PDF] A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
N Moriarty, CW Gantner, CPJ Hunt, CM Ermine… - Cell Stem Cell, 2022 - cell.com
Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease (PD)
in order to provide long-term improvement in motor functions. The limited capacity for long-…
in order to provide long-term improvement in motor functions. The limited capacity for long-…
Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke
Background and Purpose— Human amnion epithelial cells (hAECs) are nonimmunogenic,
nontumorigenic, anti-inflammatory cells normally discarded with placental tissue. We …
nontumorigenic, anti-inflammatory cells normally discarded with placental tissue. We …
[PDF][PDF] Viral delivery of GDNF promotes functional integration of human stem cell grafts in Parkinson's disease
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are
capable of functionally integrating following transplantation and have recently advanced to …
capable of functionally integrating following transplantation and have recently advanced to …
[HTML][HTML] Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
IR de Luzy, KCL Law, N Moriarty, CPJ Hunt… - Nature …, 2021 - nature.com
Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to
generate appropriate neuronal progenitors suitable for transplantation in Parkinson’s disease…
generate appropriate neuronal progenitors suitable for transplantation in Parkinson’s disease…
[HTML][HTML] Identification of cell barcodes from long-read single-cell RNA-seq with BLAZE
Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA isoforms
in individual cells. However, long-read scRNA-seq using the Oxford Nanopore platform …
in individual cells. However, long-read scRNA-seq using the Oxford Nanopore platform …
Tissue programmed hydrogels functionalized with GDNF improve human neural grafts in Parkinson's disease
CPJ Hunt, V Penna, CW Gantner… - Advanced Functional …, 2021 - Wiley Online Library
The survival and synaptic integration of transplanted dopaminergic (DA) progenitors are
essential for ameliorating motor symptoms in Parkinson's disease (PD). Human pluripotent stem …
essential for ameliorating motor symptoms in Parkinson's disease (PD). Human pluripotent stem …
Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian …
…, CW Gantner, JA Kauhausen, CPJ Hunt… - Journal of …, 2019 - Soc Neuroscience
Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of
degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease. Despite …
degenerated ventral midbrain dopaminergic (vmDA) neurons in Parkinson's disease. Despite …
[PDF][PDF] A PITX3-EGFP reporter line reveals connectivity of dopamine and non-dopamine neuronal subtypes in grafts generated from human embryonic stem cells
Development of safe and effective stem cell-based therapies for brain repair requires an in-depth
understanding of the in vivo properties of neural grafts generated from human stem …
understanding of the in vivo properties of neural grafts generated from human stem …