User profiles for Catherine B. Kirn-Safran
Catherine SafranVerified email at widener.edu Cited by 1501 |
Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity
…, C Jiang, S Yoo, NC Schanen, CB Kirn‐Safran… - The EMBO …, 2011 - embopress.org
Subcellular localization of mRNAs is regulated by RNA–protein interactions. Here, we show
that introduction of a reporter mRNA with the 3′UTR of β‐actin mRNA competes with …
that introduction of a reporter mRNA with the 3′UTR of β‐actin mRNA competes with …
[HTML][HTML] The dependences of osteocyte network on bone compartment, age, and disease
Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular
pore system (LCS) buried within the mineralized matrix, which allows osteocytes to …
pore system (LCS) buried within the mineralized matrix, which allows osteocytes to …
Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone
…, KJ Czymmek, CB Kirn‐Safran… - Journal of Bone and …, 2011 - academic.oup.com
Osteocytes project long, slender processes throughout the mineralized matrix of bone, where
they connect and communicate with effector cells. The interconnected cellular projections …
they connect and communicate with effector cells. The interconnected cellular projections …
Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release
AK Jha, W Yang, CB Kirn-Safran, MC Farach-Carson… - Biomaterials, 2009 - Elsevier
We have developed a biomimetic growth factor delivery system that effectively stimulates
the chondrogenic differentiation of the cultured mesenchymal stem cells via the controlled …
the chondrogenic differentiation of the cultured mesenchymal stem cells via the controlled …
Perlecan‐containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar‐canalicular system
The pericellular matrix (PCM), a thin coating surrounding nearly all mammalian cells, plays
a critical role in many cell‐surface phenomena. In osteocytes, the PCM is believed to control …
a critical role in many cell‐surface phenomena. In osteocytes, the PCM is believed to control …
Axonal localization of transgene mRNA in mature PNS and CNS neurons
…, AW English, NC Schanen, CB Kirn-Safran… - Journal of …, 2011 - Soc Neuroscience
Axonal mRNA transport is robust in cultured neurons but there has been limited evidence for
this in vivo. We have used a genetic approach to test for in vivo axonal transport of reporter …
this in vivo. We have used a genetic approach to test for in vivo axonal transport of reporter …
Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29
CB Kirn‐Safran, DS Oristian, RJ Focht… - … Dynamics: An Official …, 2007 - Wiley Online Library
Because of their deleterious effects on developing organisms, ribosomal protein (RP) mutations
have been poorly described in mammals, and only a few heterozygous mutations have …
have been poorly described in mammals, and only a few heterozygous mutations have …
Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis
The goal of this study was to use bioengineered injectable microgels to enhance the action
of bone morphogenetic protein 2 (BMP2) and stimulate cartilage matrix repair in a reversible …
of bone morphogenetic protein 2 (BMP2) and stimulate cartilage matrix repair in a reversible …
Heparan sulfate proteoglycans and their binding proteins in embryo implantation and placentation
CB Kirn-Safran, SS D'Souza, DD Carson - Seminars in cell & …, 2008 - Elsevier
Complex interactions occur among embryonic, placental and maternal tissues during embryo
implantation. Many of these interactions are controlled by growth factors, extracellular …
implantation. Many of these interactions are controlled by growth factors, extracellular …
Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis
CB Kirn‐Safran, RR Gomes, AJ Brown… - … Research Part C …, 2004 - Wiley Online Library
Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both
developing and mature cartilage. Increasing evidence indicates that the action of numerous …
developing and mature cartilage. Increasing evidence indicates that the action of numerous …