User profiles for Catriona McLean
Catriona McLeanMonash University, Alfred Hospital, MHRI, Melbourne University Verified email at monash.edu Cited by 44929 |
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
Genetic evidence strongly supports the view that Aβ amyloid production is central to the cause
of Alzheimer's disease. The kinetics, compartmentation, and form of Aβ and its temporal …
of Alzheimer's disease. The kinetics, compartmentation, and form of Aβ and its temporal …
[HTML][HTML] Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective therapeutic
intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Aβ deposits in AD, …
intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Aβ deposits in AD, …
[HTML][HTML] Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis …
Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …
subtypes that are biologically distinct and behave differently. The aim of this study was to …
[PDF][PDF] TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS/STING in ALS
…, KR Balka, DJ Calleja, F Moghaddas, E Ni, CA McLean… - Cell, 2020 - cell.com
Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic
lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to …
lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to …
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies
Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. …
[HTML][HTML] Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
…, HH Cho, D Galatis, RD Moir, CL Masters, C McLean… - Cell, 2010 - cell.com
Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe 2+ elevation as
well as extracellular Zn 2+ accumulation within amyloid plaque. We found that the AD β-…
well as extracellular Zn 2+ accumulation within amyloid plaque. We found that the AD β-…
Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
RMD Holsinger, CA McLean… - Annals of neurology …, 2002 - Wiley Online Library
β‐Secretase cleavage represents the first step in the generation of Aβ polypeptides and
initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease. By …
initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease. By …
[HTML][HTML] Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
RA Cherny, JT Legg, CA McLean, DP Fairlie… - Journal of Biological …, 1999 - ASBMB
Zn(II) and Cu(II) precipitate Aβ in vitro into insoluble aggregates that are dissolved by metal
chelators. We now report evidence that these biometals also mediate the deposition of Aβ …
chelators. We now report evidence that these biometals also mediate the deposition of Aβ …
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and
Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies …
Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies …
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation
There is currently little information available about how individual cell types contribute to
Alzheimer’s disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …
Alzheimer’s disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …