User profiles for Charles J. Heckman

CJ Heckman

Physiology, Northwestern University
Verified email at northwestern.edu
Cited by 11549

Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors

…, X Li, RLW Harris, EW Ballou, R Anelli, CJ Heckman… - Nature medicine, 2010 - nature.com
Muscle paralysis after spinal cord injury is partly caused by a loss of brainstem-derived
serotonin (5-HT), which normally maintains motoneuron excitability by regulating crucial …

Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo

RH Lee, CJ Heckman - Journal of Neuroscience, 2000 - Soc Neuroscience
The impact of neuromodulators on active dendritic conductances was investigated by the
use of intracellular recording techniques in spinal motoneurons in the adult cat. The well …

Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice

…, R Fu, PR Bar, R Anelli, CJ Heckman… - Journal of …, 2004 - journals.physiology.org
ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative
disease characterized by a progressive and selective loss of motoneurons. Transgenic mice …

Motoneuron Excitability and Muscle Spasms Are Regulated by 5-HT2B and 5-HT2C Receptor Activity

…, EW Ballou, CJ Heckman… - Journal of …, 2011 - journals.physiology.org
Immediately after spinal cord injury (SCI), a devastating paralysis results from the loss of brain
stem and cortical innervation of spinal neurons that control movement, including a loss of …

Serotonin affects movement gain control in the spinal cord

…, Q Wang, TG Hornby, CJ Heckman… - Journal of …, 2014 - Soc Neuroscience
A fundamental challenge for the nervous system is to encode signals spanning many orders
of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems …

Robust and accurate decoding of motoneuron behaviour and prediction of the resulting force output

…, RK Powers, D Farina, CJ Heckman - The Journal of …, 2018 - Wiley Online Library
Key points The spinal alpha motoneuron is the only cell in the human CNS whose discharge
can be routinely recorded in humans. We have reengineered motor unit collection and …

Hill muscle model errors during movement are greatest within the physiologically relevant range of motor unit firing rates

EJ Perreault, CJ Heckman, TG Sandercock - Journal of biomechanics, 2003 - Elsevier
This study evaluated the accuracy of Hill-type muscle models during movement. Hill-type
models are ubiquitous in biomechanical simulations. They are attractive because of their …

Effects of exercise training on α-motoneurons

P Gardiner, Y Dai, CJ Heckman - Journal of applied …, 2006 - journals.physiology.org
Evidence is presented that one locus of adaptation in the “neural adaptations to training” is
at the level of the α-motoneurons. With increased voluntary activity, these neurons show …

The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons

…, RK Powers, CJ Heckman - Journal of …, 2017 - journals.physiology.org
Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be
easily recorded in human subjects. This is because of the one-to-one relationship between …

Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study

…, WZ Rymer, CJ Heckman - Journal of …, 2012 - journals.physiology.org
Motoneuron discharge patterns reflect the interaction of synaptic inputs with intrinsic
conductances. Recent work has focused on the contribution of conductances mediating persistent …