The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in
mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, …

Background During the last two decades progress in the genetics of aging in invertebrate
models such as C. elegans and D. melanogaster has clearly demonstrated the existence of …

Nearly all studies of Drosophila melanogaster courtship have focused exclusively on male
behaviour. Female precopulatory behaviour is often relegated to ‘accept’ or ‘reject’ mating, …

Spinocerebellar ataxia 7 (SCA7) is a neurodegenerative disease caused by a polyglutamine
(polyQ) expansion in the ataxin 7 (ATXN7) protein, a member of a multiprotein complex …

Animal models are necessary tools for solving the most serious challenges facing medical
research. In aging and neurodegenerative disease studies, rodents occupy a place of choice. …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and
lower motor neurons. As a consequence, ALS patients display a locomotor disorder related to …

Mushroom bodies (MB) are substructures in the Drosophila brain that are essential for
memory. At present, MB anatomy is rather well described when compared to other brain areas, …

In recent decades, Drosophila mushroom bodies (MBs) have become a powerful model for
elucidating the molecular mechanisms underlying brain development and function. We have …

Neuroblastoma, a sympathetic nervous system tumor, accounts for 15% of cancer deaths in
children. In contrast to most human tumors, p53 is rarely mutated in human primary …

Parkinson’s disease (PD) is a progressive CNS disorder that is primarily associated with
impaired movement. PD develops over decades and is linked to the gradual loss of dopamine …