[PDF][PDF] Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

M de la Fuente Revenga, B Zhu, CA Guevara, LB Naler… - Cell reports, 2021 - cell.com
Clinical evidence suggests that rapid and sustained antidepressant action can be attained
with a single exposure to psychedelics. However, the biological substrates and key mediators …

Non-motor symptoms of Parkinson's disease: the neurobiology of early psychiatric and cognitive dysfunction

A Hussein, CA Guevara, P Del Valle… - The …, 2023 - journals.sagepub.com
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that has been
recognized for over 200 years by its clinically dominant motor system impairment. There are …

Estrous cycle mediates midbrain neuron excitability altering social behavior upon stress

MR Shanley, Y Miura, CA Guevara… - Journal of …, 2023 - Soc Neuroscience
The estrous cycle is a potent modulator of neuron physiology. In rodents, in vivo ventral
tegmental area (VTA) dopamine (DA) activity has been shown to fluctuate across the estrous …

LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress

CA Guevara, BA Matikainen-Ankney… - Journal of …, 2020 - journals.physiology.org
Parkinson’s disease (PD) risk is increased by stress and certain gene mutations, including
the most prevalent PD-linked mutation LRRK2-G2019S. Both PD and stress increase risk for …

Microglia and reactive oxygen species are required for behavioral susceptibility to chronic social defeat stress

CA Guevara, P Del Valle… - Journal of Neuroscience, 2020 - Soc Neuroscience
Psychosocial stress occurs in response to a potentially life-threatening interaction and leaves
a lasting impact that can be detected and measured physiologically and psychologically. …

[PDF][PDF] Development and cadherin-mediated control of prefrontal corticostriatal projections in mice

RE Mesías, Y Zaki, CA Guevara, LG Friedman… - Iscience, 2023 - cell.com
Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal
striatum. To assess how these projections form, we measured PFC axon patterning, synapse …

The Moduli of Glued Subalgebras and Moduli of Singular Curves

C Guevara - 2023 - search.proquest.com
Algebraic geometers have long been interested in the problem of classifying curves over an
algebraically closed field. The moduli space of smooth curves of fixed genus has been …

Chronic food restriction enhances dopamine-mediated intracranial self-stimulation

FG Gnazzo, D Mourra, CA Guevara, JA Beeler - Neuroreport, 2021 - journals.lww.com
Dopamine-mediated reinforcement and behavioral adaptation is essential to survival. Here,
we test the effects of food restriction on dopamine-mediated learning and reinforcement …

[HTML][HTML] Cyfip1 regulates SynGAP1 at hippocampal synapses

A Sahasrabudhe, F Begum, CA Guevara… - Frontiers in Synaptic …, 2021 - frontiersin.org
In humans, copy number variations in CYFIP1 appear to have sweeping physiological and
structural consequences in the brain, either producing or altering the severity of intellectual …

Parkinson′ s-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificity

S Gupta, CA Guevara, A Tielemans, GW Huntley… - bioRxiv, 2023 - biorxiv.org
Parkinson's (PD) is a multi-factorial disease that affects multiple brain systems and circuits.
While defined by motor symptoms caused by degeneration of brainstem dopamine neurons, …