More than 200 genes annotated as Na + /H + hydrogen exchangers (NHEs) currently reside
in bioinformation databases such as GenBank and Pfam. We performed detailed …

The relationship between endosomal pH and function is well documented in viral entry,
endosomal maturation, receptor recycling, and vesicle targeting within the endocytic pathway. …

Genetic studies in yeast, plants, insects, and mammals have identified four universally
conserved proteins, together called Vps Class C, that are essential for late endosome and …

The intestinal and renal proximal tubule brush border (BB) Na + –H + exchanger NHE3 binds
to members of the NHERF (Na + –H + exchanger regulatory factor) family. These are four …

Since the discovery of the first intracellular Na + /H + exchanger in yeast, Nhx1, multiple
homologs have been cloned and characterized in plants. Together, studies in these organisms …

Traffic through late endolysosomal compartments is regulated by sequential signaling of small
G proteins of the Rab5 and Rab7 families. The Saccharomyces cerevisiae Vps-C protein …

Rab guanosine triphosphatases (GTPases) are pivotal regulators of membrane identity and
dynamics, but the in vivo pathways that control Rab signaling are poorly defined. Here, we …

Myopathies are a clinically and etiologically heterogeneous group of disorders that can range
from limb girdle muscular dystrophy (LGMD) to syndromic forms with associated features …

Protons, the smallest and most ubiquitous of ions, are central to physiological processes.
Transmembrane proton gradients drive ATP synthesis, metabolite transport, receptor recycling …

Endosomal Na + /H + exchangers are important for salt and osmotolerance, vacuolar pH
regulation, and endosomal trafficking. We show that the C terminus of yeast Nhx1 interacts with …