The antimitotic nucleoside cytosine arabinoside (araC) causes apoptosis in postmitotic
neurons for which two mechanisms have been suggested: (1) araC directly inhibits a trophic …

Abstract Characterization of the composition of the postsynaptic proteome (PSP) provides a
framework for understanding the overall organization and function of the synapse in normal …

Understanding the origins and evolution of synapses may provide insight into species
diversity and the organization of the brain. Using comparative proteomics and genomics, we …

Phosphorylation-dependent changes in AMPA receptor function have a crucial role in
activity-dependent forms of synaptic plasticity such as long-term potentiation (LTP) and long-term …

The cellular complexity of the brain (some estimate that there are up to 10 3 different cell
types) is exceeded by the synaptic complexity, with each of the ∼10 11 neurons in the brain …

Global biological datasets generated by genomics, transcriptomics, and proteomics provide
new approaches to understanding the relationship between the genome and the synapse. …

During development of the amniote peripheral nervous system, the initial trajectory of primary
sensory axons is determined largely by the action of axon repellents. We have shown …

Introduction There is strong evidence that exercise prevents falls in community-dwelling older
people. This review summarises trial and participant characteristics, intervention contents …

Deregulation of mitogen-activated protein kinase (MAPK) signaling leads to development of
pancreatic cancer. Although Ras-mutation-driven pancreatic tumorigenesis is well …

Crossroads is a rich, multidisciplinary collection of contemporary thought on rites of
passage from leading psychologists, anthropologists, social and religious leaders, medical …