Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer
disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent …

The presynaptic protein α-synuclein is a prime suspect for contributing to Lewy pathology
and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, …

Protein phosphatase 2A (PP2A) plays central roles in development, cell growth and
transformation. Inactivation of the gene encoding the PP2A catalytic subunit Cα by gene targeting …

The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens
that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance …

Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions.
These effectors may interfere with each other to efficiently control the infection process. …

Idiopathic Parkinson’s Disease (PD), dementia with Lewy bodies (DLB), and a Lewy Body
variant of Alzheimer’s Disease (LBVAD) are characterized pathologically by proteinaceous …

The vasculotropic pathogen Bartonella henselae (Bh) intimately interacts with human endothelial
cells (ECs) and subverts multiple cellular functions. Here we report that Bh specifically …

There is overall consensus that neuronal loss occurs selectively in vulnerable areas of the
brain in Alzheimer’s disease (AD) compared to age-matched normal specimens. Significant …

Lewy pathology is a defining hallmark of degeneration neurons in postmortem brain tissue
of patients with neurodegenerative disorders including idiopathic Parkinson's disease, …

P2-108 Stages of amyloid deposition and plaque types in different APP transgenic mice as
compared to AD